黄连消渴颗粒提取工艺改进的研究  

Improvement on the Extraction Technology of Huang-lian-xiao-ke Granule

作　　者：邓月婷[1] 马超英[1] 陈陆[1] 蒋合众[1] 李燕[1] 

机构地区：[1]西南交通大学药学院,四川峨眉山614202

出　　处：《时珍国医国药》2009年第5期1070-1071,共2页Lishizhen Medicine and Materia Medica Research

基　　金：教育部"春晖计划"科研合作项目(No.Z2005-1-51002)

摘　　要：目的改进黄连消渴颗粒的提取工艺。方法分别以盐酸小檗碱和多糖的含量为指标,采用正交设计法和单因素比较法,设计优选了黄连消渴颗粒剂的提取工艺。结果优选出的提取工艺为:黄连与原方中其余四味药分开提取;黄连粗粉浸泡30 min后,用12,10倍量水提取2次,提取时间均为1.5 h;其余4味药一起提取,浸泡30 min,加10倍量水提取1次,提取时间为1.5 h。结论该实验确定的提取工艺方法合理,稳定可行。Objective To improve the extraction technology of Huang - lian - xiao - ke Granule. Methods The extraction technology for Huang - lian - xiao - ke Granule was optimized through single comparative and orthogonal law with the use of the extraction rate of berberine hydrochloride and polysaccharide as the assessment index. Results The optimized extraction technology for Huang - lian - xiao - ke Granule was as follows ： Copis chirtertsis Franch. and the other four kinds of raw materials in the origin prescription were decocted separately; after soaked for 30min, the coarse powder of Copis chinertsis Franch was decocted with 12, 10 times water each time and both for 1.5h; after soaked for 30min, the four kinds of raw materials were decocted together for 1.5h just one time with 10 times water. Conclusion The extraction technology is reasonable, stable and easy to operate.

关 键 词：盐酸小檗碱 多糖 提取工艺 

分 类 号：R284.2[医药卫生—中药学]