两种木贼提取物对高血脂大鼠主动脉内皮超微结构的作用  

Effect of Equisetum Extract on the Ultrastructure of Endothelial Cell in Hyperlipidemia Rats

作　　者：甄艳军[1] 姜秀娟[1] 刘志敏[1] 侯建眀 张凤梅[1] 张东辉[1] 曹华[1] 张雪静[1] 

机构地区：[1]河北医科大学基础课教学部,河北石家庄050091

出　　处：《时珍国医国药》2009年第5期1101-1102,共2页Lishizhen Medicine and Materia Medica Research

基　　金：河北省科学技术研究与发展计划项目(No.06276102D-28)

摘　　要：目的观察两种木贼提取物对动脉粥样硬化早期内皮细胞超微结构的影响。方法高脂饲料复制SD大鼠早期动脉粥样硬化模型,分别予木贼正丁醇提取物及其剩余物灌胃预防性给药9周,透射电镜观察各组主动脉内皮细胞的变化。结果木贼正丁醇提取物及其剩余物组内皮细胞超微结构均较模型组完整,吞饮小泡和脂质空泡的数量、体积明显减少,线粒体、内质网肿胀及脱颗粒现象显著减轻,且效果前者优于后者。结论两种木贼提取物均有明显改善高脂对内皮细胞超微结构损伤的作用。Objective To investigate the effect of Equisetum extract on the ultrastructure of endothelial cell in hyperlipidemia rats on early atheroselerosis stage. Methods Fifty Sprague - Dawley rates were randomly divided into five groups： the control group ted with a standard chow diet, four other groups fed with a high fat diet including one group plus Gemfibrozil Capsules, the others plus Equisetum extract and the rest. Changes of uhrastructure of endomembrane were examined by electron microscope after nine weeks. Results Compared with model group, the endotheliurn of Equisetum extract group were more intact, most of them were continuous and normol in forms, which were similar to those in Gemfibrozil Capsules group. Conclusion Equisetum extract has a protective action on uhrastructure of endothelial ceils of the aorta in the early atherosclerosis rats.

关 键 词：木贼提取物 高脂血症 内皮细胞 超微结构 

分 类 号：R285.5[医药卫生—中药学]