复方柳菊片保肝利胆作用的实验研究  

Studies on Liver-protective and Choleretic Effect of Fufang Liuju Tablet

作　　者：徐丽瑛[1] 肖小华[1] 方铝[1] 郭晟[1] 余华[1] 

机构地区：[1]江西省药物研究所,江西南昌330029

出　　处：《时珍国医国药》2009年第5期F0003-F0004,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察复方柳菊片对大鼠慢性肝损伤的保护作用和利胆、退黄作用。方法制备大鼠四氯化碳慢性肝损伤模型,观察复方柳菊片对慢性肝损伤大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白、白蛋白、A/G的影响,同时观察肝脏病理学改变。用胆管引流法测定复方柳菊片对正常大鼠胆汁量的影响。用异硫氰酸-1-萘酯造成黄疸模型,测定血清中ALT,AST和总胆红素的含量。结果复方柳菊片能明显降低由CC l4引起的大鼠慢性肝损伤血清ALT,AST值,促进肝组织修复以及肝细胞合成蛋白。复方柳菊片能明显增加大鼠胆汁分泌量,降低ANIT引起的ALT,AST和总胆红素升高。结论复方柳菊片具有保肝降酶、利胆和退黄作用。Objective To study the protective effect of Fufang Liuju Tablets on the chronic liver injury and choleretic and icterus effects. Methods CCl4 - induced chronic hepatic injury model was made in rats. Effects of Fufang Liuju Tablets on biochemical indexes such as glutamic pyruvic transaminase （ ALT）, glutamic oxaloacetie transaminase （ AST）, total protein （ TP）, albumin （ALB） ,A/G in rat serum were observed,and histopathological changes were observed. The drainage of bile duct was used to measure the influence of Fufang Liuju Tablets on the bile amount of normal rats. ANIT - induced icterus model was made in rats to observe biochemical indexes such as ALT, AST and TBIL. Results Fufang Liuju Tablet could remarkably increase the bile flow of normal rats and obviously inhibited the elevation of serum ALT of the chronic liver injury induced by CC14 , and promote the respair of kepotic tissue and hepatocellular synthesis protein. Conclusion Fufang Liuju Tablets has liver - protective and enzyme decreasing, choleretic and ieterus effect.

关 键 词：复方柳菊片 慢性肝损伤 胆汁分泌 黄疸 

分 类 号：R285.5[医药卫生—中药学]