卡马西平片体外溶出度与体内吸收相关性  

The correlation between dissolution in vitro and absorption in vivo of carbamazepine

作　　者：陈幼亭[1] 金卫坤[1] 夏运岳[1] 金鸿宾[1] 徐向毅[2] 陈寅[2] 石健[2] 

机构地区：[1]苏州医学院附属第一医院药剂科,苏州215005 [2]苏州医学院附属第一医院药学系,苏州215005

出　　处：《中国临床药学杂志》1998年第2期66-69,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的:考察卡马西平(CBZ)片溶出度与体内吸收的相关性.方法:应用ZRS-4溶出度仪测定卡马西平片的溶出度.4名男性健康志愿者po单剂量200mg CBZ,用TDx分析仪测定血药浓度,并按照Wagner-Nel- son公式计算药物吸收分数.结果:体外溶出度与体内药物吸收分数的相关系数r=0.9261,体外溶出度与体内药物吸收分数对数的相关系数r=0.9977.结论:CBZ片体外溶出度与体内吸收有较好的相关性.AIM: To study the correlation between dissolution in vitro and absorption in vivo of carbamazepine (CBZ)tablet. METHODS: Dissolution of CBZ tablet in vitro was tested with ZRS-4 dissolution tester. A single oral dose of 200mg CBZ tablet was given to 4 Chinese male volunteers of Han nationality. Plasma levels were determined with TDx analyzer and absorption fraction were calculated according to Wagner-Nelson's formula. RESULTS: The correlation coefficient (r) between dissolution in vitro and absorption fraction in vivo of CBZ tablet was 0. 926 1 .The correlation coefficient (r) between dissolution in vitro and logarithmic absorption fraction in vivo of CBZ tablet was 0. 997 7. CONCLUSION: There was a correlation between dissolution in vitro and absorption in vivo of CBZ.

关 键 词：卡马西平 体外溶出度 体内吸收 相关性 

分 类 号：R971.6[医药卫生—药品] R969[医药卫生—药学]