A Multiple Functional Protein:the Herpes Simplex Virus Type 1 Tegument Protein VP22  

作　　者：Mei-li LI Hong GUO Qiong DING Chun-fu ZHENG 

机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071 China

出　　处：《Virologica Sinica》2009年第3期153-161,共9页中国病毒学（英文版）

基　　金：The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science (20071010- 141);National Natural Science Foundation of China (30870120);Open Research Fund Program of the State Key Laboratory of Virology of China (2007003, 2009007)

摘　　要：The herpes simplex virus type 1 （HSV-1） VP22, is one of the most abundant HSV-I tegument proteins with an average stoichiometry of 2 400 copies per virion and conserved among alphaherpesvirinae. Many functions are attributed to VP22, including nuclear localization, chromatin binding, microtubule binding, induction ofmicrotubule reorganization, intercellular transport, interaction with cellular proteins, such as template activating VP16, pU factor I （TAF-I） and nonmuscle myosin II A （NMIIA）, and viral proteins including pUS9 and pUL46, glycoprotein E （gE） and gD. Recently, many novel functions perform tegument protein ed by the HSV-1 VP22 protein have been shown, including promotion of protein synthesis at late times in infection, accumulation of a subset of viral mRNAs at early times in infection and possible transcriptional regulation function .The herpes simplex virus type 1(HSV-1) VP22,is one of the most abundant HSV-1 tegument proteins with an average stoichiometry of 2 400 copies per virion and conserved among alphaherpesvirinae. Many functions are attributed to VP22,including nuclear localization,chromatin binding,microtubule binding,induction of microtubule reorganization,intercellular transport,interaction with cellular proteins,such as template activating factor I(TAF-I) and nonmuscle myosin II A(NMIIA) ,and viral proteins including tegument protein VP16,pUS9 and pUL46,glycoprotein E(gE) and gD. Recently,many novel functions performed by the HSV-1 VP22 protein have been shown,including promotion of protein synthesis at late times in infection,accumulation of a subset of viral mRNAs at early times in infection and possible transcriptional regulation function.

关 键 词：Herpes simplex virus type 1 （HSV-1） VP22 Intercellular trafficking Protein interaction Tegument protein. 

分 类 号：Q78[生物学—分子生物学] S852.65[农业科学—基础兽医学]