绝经后期更年期综合征常见证候要素的Logistic回归分析  

Logistic regression analysis on common syndrome factors of postmenopausal menopause syndrome

作　　者：杜彩凤[1] 王天芳[1] 辛意 李力[3] 任婕[4] 吴秀艳[1] 赵燕[1] 王庆国[1] 

机构地区：[1]北京中医药大学基础医学院中医诊断系,北京100029 [2]北京市回龙观社区卫生服务中心 [3]河南中医学院第一附属医院 [4]北京市石景山区中医医院

出　　处：《北京中医药大学学报》2009年第4期238-243,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2003CB517001,No.2003CB517101,No.2003CB517106)

摘　　要：目的探讨绝经后期更年期综合征常见证候要素与症状的相关性。方法对来源于全国七家三级甲等医院的780例绝经后期更年期综合征门诊患者进行临床调查,在基于专家经验辨证的基础上,提取常见病位类、病性类证候要素,并运用二分类Logistic回归分析研究常见证候要素和症状之间的相关性。结果获取常见病位类证候要素肾、肝、脾、心,病性类证候要素气滞、热/火、血瘀、湿、阴虚、气虚、阳虚、虚,经对各证候要素回归模型分析,发现常见证候要素与症状的对应关系。如:弦脉、焦虑、自觉发胀、红舌、急躁易怒、脉无力、注意力不集中对判断病位类证候要素"肝"具有诊断意义;畏寒、四肢不温、夜尿频多、迟脉、便溏、齿痕舌、肌肉瞤动对判断病性类证候要素"阳虚"具有诊断意义。这与我们传统中医的认识吻合程度较高,也有个别症状对证候要素的判断意义上存在一定的争议,另外也提示精神症状对判断常见证候要素的一定意义。结论通过临床调查研究,初步分析了绝经后期更年期综合征常见证候要素与症状之间的对应关系,为建立证候要素的诊断标准提供了一定依据。Objective To discuss the correlation between the common syndrome factors and symptoms of postmenopausal menopause syndrome. Method The clinical survey was carried out in 780 outpatients with postmenopausal menopause syndrome from 7 grade Ⅲ-A hospitals in the whole country. On the basis of syndrome differentiation with expert experiences common syndrome factors of types according to the locations and natures of diseases were summed up. The correlation between common syndrome factors and symptoms were analyzed and studied by applying dichotomy Logistic regression analysis. Result The common syndrome factors of location type, including kidney, liver, spleen and heart, and syndrome factors of disease nature type, including qi stagnation, heat or fire, blood stasis, dampness, yin deficiency, qi deficiency, yang deficiency and deficiency were obtained. The correlation between the common syndrome factors and symptoms was found through the analysis on the regression model of common syndrome factors. For example, stringy pulse, anxious, distention, red tongn concentration were diagnostically significant in the judgment e, irascibility, weakness pulse and lack of of liver, one of syndrome factors of location type, while fear of cold, cold limbs, frequent tongue and muscle tremor were diagnostically syndrome factors of disease nature type. These regression model. There were some contentious and mental symptoms were significant to the jurination at night, slow pulse, loose stool, teeth-printed significant in the judgment of yang deficiency, one of tallied with the knowledge of TCM after the analysis on the symptoms to the judgment significance of syndrome factors, udgment of common syndrome factors. Conclusion The correlation between the common syndrome factors and symptoms of postmenopausal menopause syndrome was analyzed initially through clinical study, which provides a foundation for the diagnostic standard of syndrome factors.

关 键 词：更年期综合征 绝经后期 证候要素 LOGISTIC回归分析 

分 类 号：R271.911.75[医药卫生—中西医结合]