两种注射用第一类疫苗同时接种的安全性  

Safety of Simultaneous Inoculation with Two Kinds of Vaccines Included in National Immunization Program

作　　者：庞红[1] 吴美华[1] 

机构地区：[1]上海市长宁区疾病预防控制中心免疫预防科,上海200051

出　　处：《中国生物制品学杂志》2009年第5期493-495,共3页Chinese Journal of Biologicals

摘　　要：目的分析两种注射用第一类疫苗同时接种后预防接种不良事件(AEFI)的发生率,以评价其安全性。方法通过上海市长宁区9个社区预防接种门诊现场2006年3月～2007年12月登记流水册,统计乙型肝炎疫苗(HepB)第3针、A群脑膜炎球菌多糖疫苗(MCV-A)第1针、麻疹疫苗(MV)第1针和乙脑疫苗(JEV)第1针单独及同时接种的人数,计算AEFI的发生率。结果单独接种HepB第3针和MCV-A第1针的AEFI的发生率分别为5.86‰和3.74‰,同时接种时为1.18‰;单独接种MV和JEV第1针的AEFI发生率分别为3.59‰和9.24‰,同时接种时为1.93‰。同种疫苗不同厂家之间,或相同厂家不同包装剂量之间,AEFI发生率差异较大。AEFI发生率在6～12月龄儿童中较高。结论两种注射用第一类疫苗同时接种不会增加AEFI的发生率,为减少接种次数,可推荐同时接种。Objective To analyze the incidence rate of adverse events following immunization （AEFI） and evaluate the safety of simultaneous inoculation with two kinds of vaccines included in National Immunization Program （NIP）. Methods The data on subjects inoculated with the 3rd dose of hepatitis B vaccine （HepB）, the 1st dose of group A meningoeoccus polysaccharide vaccine （MCV-A）, the 1st dose of measles vaccine （MV） and the 1st dose of Japanese encephalitis vaccine （JEV） during March 2006 to December 2007 in 9 immunization clinics in Changning District, Shanghai City were collected, based on which the incidence rates of AEFI of vaccines inoculated alone and simuhaneously were calculated. Results The incidence rates of the 3rd dose of HepB and the 1st dose of MCV-A inoculated alone were 5.86%0 and 3.74%v respectively, while that of the two kinds of vaccine inoculated simultaneously was 1. 18%~. However, the incidence rates of the 1st dose of MV and the 1st dose of JEV inoculated alone were 3. 59‰ and 9. 24‰ respectively, while that of the two kinds of vaccine inoculated simultaneously was 1. 93‰ Significant differences were observed in the incidence rates of same vaccines manufactured by various manufacturers or by the same manufacturer in various packages. The incidence rate of AEFI in infants aged 6 - 12 months was relatively high. Conclusion The incidence rate of AEFI of two kinds of vaccines included in NIP inoculated simultaneously showed no significant increase as compared with those inoculated alone. Two kinds of vaccines included in NIP may be recommended to be inoculated simultaneously to decrease the doses.

关 键 词：国家免疫规划 预防接种不良事件 安全性 

分 类 号：Q819[生物学—生物工程] R392[医药卫生—免疫学]