日本血吸虫新型疫苗的研究进展  

Development of Research on Novel Schistosomiasis japonicum Vaccine

作　　者：翟羽佳[1,2] 刘全[1] 

机构地区：[1]军事医学科学院军事兽医研究所,长春130062 [2]吉林农业大学生命科学学院,长春130118

出　　处：《中国生物制品学杂志》2009年第5期511-514,共4页Chinese Journal of Biologicals

基　　金：国家科技支撑计划(2006BAD06A09)

摘　　要：日本血吸虫病是一种严重危害人类及家畜健康的人兽共患寄生虫病,研制疫苗是防治血吸虫感染的有效措施。传统疫苗因成本高、免疫原性低及存在安全隐患,使其应用受到限制,开发新型疫苗成为必然趋势。随着免疫学和分子生物学的快速发展,近年来出现了各种新型疫苗。本文就基因工程亚单位疫苗、合成肽疫苗、核酸疫苗、重组活载体疫苗和抗独特型抗体疫苗的研究进展、各新型疫苗的优缺点及应用前景作一综述。Schistosomiasis japonica is one of the most serious parasitic disease that threaten the health of humans and livestock. The development of vaccine is an effective measure for the prevention and control of the infectious disease. It is necessary to develop novel Schistosomiasis japonicum vaccines since the application of traditional vaccines is restricted due to their high cost, low immunogenicity and low safety. With the rapid progresses in immunology and molecular biology, various novel Schistosomiasis japon- icum vaccine have been developed in recent years. The development of research on recombinant subunit vaccine, synthetic peptide vaccine, DNA vaccine, recombinant live vector vaccine and anti-idiotype antibody vaccine as well as advantages, shortcomings and prospects of the vaccines are reviewed in this paper.

关 键 词：日本血吸虫 新型疫苗 

分 类 号：R383.24[医药卫生—医学寄生虫学]