三种自身抗体对原发性舍格伦综合征诊断的临床意义  

The Evaluation of three types of autoantibodies in diagnosis of patients with primary Sjgren's syndrome

作　　者：林琴[1] 黄建荣[2] 华红[2] 

机构地区：[1]北京大学口腔医学院检验科,100081 [2]北京大学口腔医学院中医黏膜科,100081

出　　处：《现代口腔医学杂志》2009年第3期225-227,共3页Journal of Modern Stomatology

摘　　要：目的探讨抗腮腺导管抗体、抗核抗体及抗ENA抗体对于原发性舍格伦综合征(primary Sjgren's syndrome,pSS)诊断的意义。方法采用生物薄片免疫荧光技术(BIOGHDP-IFA)及间接免疫荧光法,对32例确诊的原发性舍格伦综合征患者血清中的抗腮腺导管抗体、抗核抗体(ANA)及抗ENA抗体进行测定,并与正常对照组比较。结果原发性舍格伦综合征组抗腮腺导管抗体阳性率为50%,ANA阳性率为84.3%,抗ENA抗体阳性率达100%。抗腮腺导管抗体在原发性干燥综合征中的应用价值有待进一步探讨,抗核抗体和抗ENA抗体仍是目前该病血清学诊断的重要指标。结论ANA和抗ENA抗体对于诊断pSS的敏感性和特异性都较高。Objective To evaluate three types of autoantibodies in diagnosis of patients with primary Sjfigren＇s syndrome （pSS）. Methods ANA, ENA and anti - duct antibodies were tested in 32 pSS patients and 30 healthy controls . BIOGHDP - IFA assay were used in this study. Results The positive rate of anti - duct antibody and ANA as well as ENA antibody were 50%, 84.3% and 100% respectively in pSS group. Conclusion ENA and ANA antibodies were still a sensitve and specific serum test for diagnosing of pSS.

关 键 词：原发性舍格伦综合征 抗核抗体 抗ENA抗体 抗腮腺导管抗体 

分 类 号：R593.2[医药卫生—内科学] R781.7[医药卫生—临床医学]