208株住院患者鲍曼不动杆菌的耐药性分析  

Drug Resistance of Acinetobacter Baumanii:Analysis of 208 Strains

作　　者：钟劲松[1] 林耀堂[1] 张彦东[1] 

机构地区：[1]珠海市人民医院,珠海市519000

出　　处：《中国医院用药评价与分析》2009年第5期364-365,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解我院临床分离的鲍曼不动杆菌的分布特点及耐药情况,为临床合理用药提供参考。方法:对我院2007年1月～2008年10月住院患者送检标本分离的208株鲍曼不动杆菌的分布及药敏结果进行回顾性分析。结果:我院鲍曼不动杆菌检出率为3.08%,最常出现在痰标本中,占88.9%;鲍曼不动杆菌感染主要以呼吸内科最多,其次为儿科及ICU。该菌对亚胺培南、美洛培南仍保持很高的敏感性,敏感率均达98.6%,对多粘菌素E、氨苄西林/舒巴坦及头孢吡肟也比较敏感,敏感率分别为86.5%、70.2%、62.0%;耐药率超过50%的抗菌药物有头孢噻吩(100%)、头孢西丁(94.7%)头孢呋辛(88.9%)、阿莫西林(59.1%)、阿莫西林/克拉维酸(54.3%)、替卡西林(53.4%)、庆大霉素(50.5%),对其它抗菌药物的耐药率在32.2%～49.5%。结论:鲍曼不动杆菌是医院感染重要的条件致病菌,其对抗生素耐药率高,且多重耐药,碳青酶烯类是治疗鲍曼不动杆菌最敏感的抗菌药物,氨苄西林/舒巴坦是经验治疗鲍曼不动杆菌感染优选抗菌药物。OBJECTIVE： To study the distribution and the drug resistance of Acinetobacter baumanii in our hospital for reference of rational use of antibiotics. METHODS ： The distribution and the susceptibility results of Baumanii in our hospital from Jan. 2007 to. Oct. 2008 were analyzed retrospectively. RESULTS： The isolating rate of Acinetobacter baumanii stood at 3.08%, of which, 88.9 % were noted in sputum specimen. Department of respiratory diseases showed the highest proportion of Acinetobacter baumanii, followed by pediatrics and ICU. Acinetobacter baumanii were highly sensitive to Imipenem and Meropenem, with susceptible rates of both reaching 98.6 %, and which were also sensitive to polymyxin E, ampicillin/sulbactam and cefepime, with susceptible rates reaching 86.5 % , 70.2% and 62.0% , respectively. The drugs with antibiotic resistance rate exceeding 50% were as follows： Cefalotin （100%）, cefoxitin （94. 7%）, cefuroxime （88.9%）, amoxicillin （59. 1%）, amoxicillin - clavulanic acid （54. 3 %）, ticarcillin （53.4%） and gentamicin （50.5%）. The drug resistance rates of Acinetobacter baumanii to other antibacterial stood at 32.2% -49.5%. CONCLUSION： Acinetobacter baumanii are the predominant opportunistic pathogenic bacteria in nosocomial infection, which are highly resistant and muhiresistant to antibiotics. Carbapenem is the most susceptible antibacterial drug for Acinetobaeter baumanii, and ampicillin/sulbactam are the preferred empirical antibacterial therapy for Acinetobacter baumannii.

关 键 词：鲍曼不动杆菌 耐药性 医院感染 

分 类 号：R978.1[医药卫生—药品]