50例系统性红斑狼疮患者血脂水平分析  

Analysis of blood lipids level in 50 patients of systemic lupus erythematosus

作　　者：王涛[1] 陈琳洁[1] 李志军[1] 王旸[1] 梅永君[1] 

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,233004

出　　处：《安徽医学》2009年第4期377-379,共3页Anhui Medical Journal

摘　　要：目的探讨系统性红斑狼疮(SLE)患者血脂的变化及其临床意义。方法检测18例初诊未用激素治疗、32例已用激素治疗的SLE患者和30例正常健康体检者的血脂水平,并分析其变化与临床病情资料的相关性。结果SLE患者组血清胆固醇(TC)和三酰甘油(TG)水平明显高于对照组(P<0.01),HDL水平显著低于对照组降低(P<0.05)。有肾脏病变SLE患者组TG水平明显高于无肾脏病变SLE患者组(P<0.01),TC和HDL水平在两组间差别无统计学意义(P>0.05)。SLE应用激素治疗组血清TC和TG水平明显高于对照组(P<0.01),HDL水平在两组间差别无统计学意义(P>0.05)。另外HDL水平与血沉(ESR)呈负相关。结论系统性红斑狼疮患者血脂异常主要系肾脏损害和大剂量激素使用所致。Objective To investigate the changes and the clinical significances of blood lipids in patients with systemic lupus erythematosus （SLE）. Methods Samples taken from 18 patients of SLE who hadn＇t been treated with steroid, 32 patients of SLE who had been treated with steroid and 30 healthy controls were assessed for total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）. Resealts A significant elevation of TC,TG levels and reduction of HDL level were observed in the SLE patients compared to that of controls （ P 〈 0. 05）. The level of TG were higher in SLE patients who had renal involvement than that of SLE patients who hadn＇t renal involvement （ P 〈 0. 05）, but there had no significant difference in TC and HDL between the two groups （ P 〉 0. 05） .The level of TG and TC were higher in SLE patients who had been treated with steroid than that of SLE patients who hadn＇t been treated with steroid （ P 〈 0. 01）, but there had no significant difference in HDL between the two groups （P 〉 0. 05） . Moreover, HDL levels were found to be negatively correlated with ESR. Conclusion The abnormal blood lipids levels in SLE patients is mostly associated with renal involvement and high dose corticosteroids.

关 键 词：红斑狼疮 系统性 血脂 

分 类 号：R593.241[医药卫生—内科学]