α-四(4-羧基苯氧基)酞菁锌的合成与抗肿瘤活性研究  

Study on synthesis and antineoplastic activity of α-tetra-(4-carboxyphenoxy)phthalocyanine zinc

作　　者：邬洪源[1] 陈伟[1] 李涛[2] 王玉[2] 夏春辉[2] 李晓丽[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院,黑龙江齐齐哈尔161042

出　　处：《辽宁师范大学学报（自然科学版）》2009年第1期94-97,共4页Journal of Liaoning Normal University:Natural Science Edition

基　　金：黑龙江省自然科学基金重点项目(D200822);齐齐哈尔市重点科技项目(GY05-19)

摘　　要：通过2步合成了水溶性的α-四(4-羧基苯氧基)酞菁锌(Ⅱ),采用UV-Vis、IR、元素分析、激光解吸电离飞行时间质谱(TOF-MS)对配合物进行了表征.在光诱导条件下,采用四甲基偶氮唑蓝比色法(MTT法),研究了此酞菁锌配合物对Bel-7402细胞抑制作用,考察了不同浓度的配合物对抑瘤效果的影响,当浓度为100 mg.L-1时对肿瘤的抑制率可达71%左右,并确定其细胞生长抑制50%时的药物浓度(即IC50值)为21 mg.L-1.结果发现:此酞菁锌是1种很有潜力的抗癌光敏剂,在光诱导条件下,适宜的浓度具有较高的抑制率,并探讨了其抑瘤机制.A novel water soluble α-tetra-（p-carboxyphenoxy） phthalocyanine zinc（ Ⅱ ） has been synthesized by two-step. It was characterized by using UV-Vis absorption spectra, IR spectra, elemental analysis and TOF-MS. The damaging effect of phthalocyanine complex on human Bel-7402 liver cancer cell were investigated by means of HE dye method and MTT colorimetric assay under condition of photoinduce. The influence of phthalocyanine complex concentration on cancer inhibition were systemic studied, which showed that it can reach 71% under the concentration of 100 mg.L^-1 for Bel-7402 ceils. Its IC50 numerical value was 21 mg.L^-1. The results show that the phthalocyanine zinc（Ⅱ） is a kind of promising anticancer photosensitizer, and exhibits good inhibition effect under appropriate concentration. The inhibition mechanism was discussed.

关 键 词：酞菁锌 光诱导杀伤 BEL-7402细胞 

分 类 号：O644.12[理学—物理化学] R735.7[理学—化学]