^(99)Tc^m-HL91探测存活心肌的应用研究  

Clinical Application of ^(99)Tc^m-HL91 SPECT on Viable Myocardium Detection

作　　者：刘刚[1] 吴华[2] 吴立兵[1] 李伏燕[1] 裴之俊[1] 陈宇[1] 

机构地区：[1]郧阳医学院附属太和医院核医学科,湖北十堰442000 [2]福建医科大学附属厦门第一医院核医学科,福建厦门361006

出　　处：《郧阳医学院学报》2009年第2期140-141,144,F0003,共4页Journal of Yunyang Medical College

摘　　要：目的:研究^(99)Tc^m-HL91在缺血心肌中的显像表现,探讨^(99)Tc^m-HL91探测缺氧但存活心肌的价值。方法:18例已确诊为心肌缺血或心肌梗塞的患者均行99Tcm-MIBI与^(99)Tc^m-HL91心肌灌注SPECT显像。在心脏短轴图像上通过ROI技术,获取缺血靶区(targetarea,T)与正常非靶区(non-targetarea,NT)心肌组织的平均放射性计数,计算T/NT比值,获得99Tcm-MIBI与99Tcm-HL91在局部缺血区与正常心肌组织的放射性比值。结果:99Tcm-HL91SPECT有10例患者在99Tcm-MIBI显像的放射性稀疏或缺损区可见到明显的放射性充填,其余8例患者^(99)Tc^m-HL91显像心肌摄取不高。结论:^(99)Tc^m-HL91可选择性地被存活/乏氧心肌摄取,和99Tcm-MIBISPECT联合应用,可有效提高检测存活心肌的效能。Objective To investigate the imaging characteristic of ^99Tc^m-HL91 in the isehemie myocardium and its value on the detection of hypoxie but viable myocardium. Methods ^99Tc^m-MIBI and ^99Tc^m-HL91 SPECT were performed in 18 patients with myocardial ischemia or infarction. The mean radioactive counts of myocardium in target area and non-target area were obtained from heart short axis images with ROI technique, the radioactivity ratio of target （isehemic area） to non-target （normal area） were calculated. Results In 10 patients the positive ^99Tc^m-HL91 uptake was shown in the defect region of ^99Tc^m-MIBI images. However,the remaining 8 patients showed low uptake of ^99Tc^m-HL91. Conclusion ^99Tc^m-HL91 may be selectively uptaken by hypoxic but viable myocardium,and the combination of ^99Tc^m-MIBI and ^99Tc^m-HL91 SPECT may be more helpful for accurate evaluation of viable myocardium.

关 键 词：心肌灌注显像 ~99Tc^m-HL91 存活心肌 

分 类 号：R817.4[医药卫生—影像医学与核医学] R542.22[医药卫生—放射医学]