骨性关节炎细胞凋亡的研究进展  

Research Developments on Osteoarthritis(OA)Apoptosis

作　　者：韦家宁[1] 戴七一[1] 

机构地区：[1]广西中医学院,南宁530001

出　　处：《浙江中医药大学学报》2009年第3期449-451,共3页Journal of Zhejiang Chinese Medical University

摘　　要：软骨细胞凋亡在骨性关节炎(OA)的发病中具有重要作用,其凋亡的途径有NO途径和Fas途径;主要受Bcl-2基因家族、Bax、P53、ICE和c-myc基因家族调控;软骨细胞外基质的降解,可诱导软骨细胞凋亡。阐明软骨细胞凋亡在OA的发病机制中的作用,将有助于OA的防治。Cartilage apoptosis functions a lot in OA occurrence. Its apoptosis has two ways of NO and Fas, mainly controlled by Bcl-2 gene family, Bax,P53, ICE and c-myc gene family;the degeneration of cartilage cell base can induce apoptosis. It shows cartilage apoptosis function in OA occurrence, helpful to prevention and treatment of OA.

关 键 词：骨关节炎 软骨细胞 细胞凋亡 综述 

分 类 号：R683.6[医药卫生—骨科学]