C-反应蛋白在肺炎并全身炎症反应综合征中的变化及意义  

作　　者：田东波[1] 付志萍[1] 唐浩熙[1] 

机构地区：[1]清远市人民医院(暨南大学医学院第五附属医院),511500

出　　处：《当代医学》2009年第15期31-32,共2页Contemporary Medicine

摘　　要：目的探讨C-反应蛋白(CRP)在全身炎症反应综合征(SIRS)中的改变及其意义。方法动态检测80例肺炎合并SIRS患者76例非SIRS的肺炎患者和45例健康者的血清CRP水平。结果非SIRS组CRP显著高于正常对照组(P<0.05);SIRS组CRP显著高于非SIRS组(P<0.05);并发多器官功能不全综合征(MODS)者CRP水平显著高于无MODS者(P<0.05)。具有SIRS诊断标准3项以上和第7天CRP持续不降的患者,发生多器官功能不全综合征(MODS)率明显增高(P<0.05)。结论CRP在SIRS的发生、发展中起重要作用;CRP检测有助于准确评估肺炎病情的危重度;持续监测CRP可能有助于预估MODS的发生。Objective To assess the changes and significance of C-reactive protein （CRP） in pneumonia associated with systemic inflammatory response syndrome（SIRS）. Methods Levels of CRP were measured in 80 patients with pneumonia associated with SIRS （serving as group A）,and 76 with pneumonia of non- SIRS （as group B） and 45 healthy people （as group C）. Results The levels of serum CRP was significantly higher in group B than in control group （P〈0.05）. The levels of serum CRP in group A were significantly higher than in group B（P〈0.05）.The levels of serum CRP was significantly higher in patients with multiple organ Dysfunction syndrome than in those without MODS（P〈0.05）. The incidence of multiple organ dysfunction syndrome was increased significantly in group A with three items of standard diagnostic indexes for SIRS and kept high levels of CRP in the 7th day （P〈0.05）. Conclusion CRP plays an important role in the occurrence and development of SIRS. The detection of serum CRP might help to accurately assess the severity of pneumonia. The continuously elevated CRP might forecast the possibility of MODS.

关 键 词：肺炎 全身炎症反应综合征 C-反应蛋白 

分 类 号：R459.7[医药卫生—急诊医学]