肝病患者肝移植前后ECR1粘附活性及数量的变化  

The changes of the adhering activity and the number of erythrocytes complete receptor 1 in patients with liver transplanting

作　　者：刘振红[1] 吕平[1] 郭静霞[1] 李永利[1] 王雪飞[1] 冯艳青[1] 王海滨[1] 

机构地区：[1]解放军第302医院临床检验中心,北京100039

出　　处：《中国实验诊断学》2009年第5期607-608,共2页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金(30471544)

摘　　要：目的研究肝移植患者ECR1粘附活性及数量的变化。方法采用红细胞天然免疫功能实验对38例肝移植、60例慢性病毒性肝炎的ECR1粘附活性进行测定,并与肝功能指标比较,采用ELISA方法测定ECR1含量变化。动态检测FK506药物浓度。结果肝移植患者移植前ECR1粘附活性和数量均低于慢性病毒性肝炎病人,但肝移植后第3天患者的ECR1粘附活性明显回升,并显著高于慢性病毒性肝炎患者(P<0.05);肝移植患者ECR1粘附活性的变化与CHE、PT及PTA等指标的变化关系密切。结论重症肝病患者恢复肝脏功能后,血清中抑制ECR1粘附活性的物质很快被清除,随后出现CR1数量的回升,提示肝病患者红细胞粘附活性的变化可作为评价肝脏移植成功的重要参考指标。Objective To study the changes of the adhering activity and the number of erythrocytes complete receptor 1 in patients with liver transplanting. Methods The assay of ECR1 immune-adhering tumor cell was used in 38 cases with liver transplanting by controlled in 60 eases with chronic hepatitis. The liver function parameter has been studied in contrasting with ECR1. The number of ECR1 has been detected by ELISA. The FK506 concentration is observed simultaneously in liver transplanting patients. Results The adhesion activity of ECR1 and the number of ECR1 is significantly raised only 3 days after transplanting, and significantly higher than fore-transplanting and the patients with chronic hepatitis（ P 〈 0.01 ）. The treatment with FK506 after transplanting can significaniiy inhibit the activity of ECR1 but no effecting to ECR1 number. The activity of ECR1 is closely related to liver function. Conclusion The ECR1 activity and the number is significantly raised after liver transplanting than fore-transplanting.And the FK506 treatment can inhibit the ECR1 adhering activity, bt no effecting on ECR1 number.

关 键 词：肝移植 ECR1 肝功能损伤 

分 类 号：R657.3[医药卫生—外科学]