miR-29b微RNA定位序列的素数组合规律  

Prime combination rule for localization sequence of miR-29b microRNA

作　　者：钱建新[1] 董克家[1] 

机构地区：[1]海南医学院转基因实验室,海南海口571101

出　　处：《海南医学院学报》2009年第6期545-547,共3页Journal of Hainan Medical University

基　　金：新世纪优秀人才支持计划资助(NCET-04-0838)~~

摘　　要：目的:探讨miR-29b微RNA定位序列的编码机制。方法:按照碱基堆积力和微RNA非编码性质,对碱基进行四进制数字编码:AUGC/0123;并且运用公式:Nmod4^n=R对微RNA序列进行模数运算和结构分析。结果:发现miR-29b微RNA的定位序列-aguguu具有素数组合规律。结论:微RNA细胞内分子邮编可能按照素数组合规律编码。Objective： To investigate code mechanism in localization sequence of miR-29b micro RNA. Methods： In accordance with the power of base stacking and the non-code nature of microRNA, the quaternary digital coding of nucleotide bases, AUGC/0123, was chosen. The microRNA sequence was analyzed by the modular formula：N mod 4^n = R. Results： It showed the hexanucleotide localizational sequence of miR-29b was a combinatorial structure of prime numbers. Conclusion ： The coding mechanism of cellular zip code of microRNAs may obey the combinatorial principle of prime number.

关 键 词：微RNA 定位序列 细胞邮编 素数组合 

分 类 号：Q78[生物学—分子生物学]