加替沙星与盐酸左旋氧氟沙星治疗急性细菌性感染的药物经济学分析  

Pharmacoeconomical analysis of gatifloxacin and levofloxacin injection in treating bacterial infections

作　　者：王玉和[1] 何勇[1] 

机构地区：[1]遵义医学院附属医院药剂科,贵州遵义563003

出　　处：《海南医学院学报》2009年第6期650-653,655,共5页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(002009001)

摘　　要：目的:评价加替沙星氯化钠注射液与盐酸左旋氧氟沙星注射液治疗急性细菌性感染的成本-效果。方法:根据文献,各种细菌感染患者204例分为两组,分别用加替沙星和左旋氧氟沙星治疗。运用药物经济学的最小成本分析法、成本-效果分析法进行分析和评价。结果:两组临床资料、疗效与不良反应均无显著性差异(P>0.05)。两组临床痊愈率和总有效率分别为66.3%、91.8%和68.9%、91.5%,治愈每例患者所需药品的最小费用为3038元和1206元;以临床总有效率计C/E分别33.1和13.2;ΔC/ΔE为5552。结论:两组临床疗效相似,而费用有显著性差异,加替沙星氯化钠注射液组总医疗费用较高,盐酸左旋氧氟沙星注射液组更具成本-效果优势。Objective： To evaluate the economicbenefit of gatifloxacin and levofloxacin injection in treatment of bacterial infections. Methods： Two hundred and four patients with bacterial infections were randomly divided into gatifloxacin and levofloxacin groups treated by gatifloxaein and levofloxacin, and were evaluated by pharmaco-economic evaluation and cost effectiveness analysis. Results： There was no significant statistic difference （P 〉 0. 05） between groups. Cure and efficacy rate of two groups were 66.3% ,91.8% ,68.9% ,91.5% ,respectively. Minimum cost of the drugs were ￥3 038 and ￥1 206 , and the clinical effective rates（C/E） were 33.1 and 13. 2,with AC/AE as 5 552. Conclusion： Two groups have similar curative effect,but gatifloxacin injection has higher medical treatment cost. So levofloxacin injection is a drug.

关 键 词：加替沙星 左旋氧氟沙星 细菌感染 经济学 药学 

分 类 号：R407.7[医药卫生—临床医学]