河南省艾滋病流行区HIV共感染HBV和HCV状况分析  

Relative analysis on HIV co-infected HBV and HCV in the area of epidemic disease,Henan

作　　者：张艳敏[1,2] 孙国清 张郑民[1] 高葆真 鲍玉洲[1,2] 

机构地区：[1]河南省眼科研究所分子生物室,郑州450003 [2]郑州大学基础医学院生物化学与分子生物学教研室,郑州450001 [3]河南省CDC性病、HIV研究所,郑州450016

出　　处：《郑州大学学报（医学版）》2009年第3期542-544,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目0624410059

摘　　要：目的:了解河南省艾滋病流行区艾滋病病毒(HIV)共感染乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)状况。方法:首先用Combas Amplicor HIV-1病毒载量检测法对从我省HIV某高发县采集的由输血感染HIV-1的130份血样进行定量测定。挑选出HIV-1病毒载量4.28×102拷贝/mL以上的血浆样本81份,同时收集30份HIV-1阴性健康体检者血浆作为对照,再用巢式PCR法对以上样本进行HBV和HCV测定。结果:81份HIV-1阳性样本中HBV阳性32份(39.5%),HCV阳性72份(88.9%);同时感染HBV和HCV的样本为7份(8.6%)。30份HIV-1阴性对照组中,HBV阳性7份(23.3%),与HIV-1阳性组间比较差异无统计学意义(χ2=2.51,P>0.05);HCV阳性4份(13.3%),与HIV-1阳性组间比较差异有统计学意义(χ2=57.88,P<0.05);HIV-1阴性对照组中未检测出HBV和HCV共感染样本,与HIV-1阳性组相比差异无统计学意义(χ2=2.77,P>0.05)。结论:经输血感染HIV的患者具有共感染HCV的倾向;对以上途径感染HIV的患者,在进行HIV治疗时应同时进行HBV和HCV检测,阳性者应在治疗HIV-1的同时给予抗HBV和HCV治疗。Aim： To investigate the relativity between HIV co-infected by HBV and HCV hy blood transfusion.Methods ：130 blood samples of HIV-I infected by blood transfusion were collected by a high epidemic county, Henan. 81 samples which HIV-I virus numbers over 4.28 x 102 copies/mL were selected and 30 blood samples of health human were collected. HBV and HCV were determined by the above samples and by nested PCR. Results： In 81 HIV-I positive sam- pies, 32 were HBV positive （39.5%） ; 72 were HCV positive （88.9%） ; 7 were HBV ＋ HCV positive （8.6%）. In 30 HIV-1 negative samples, 7 were HBV positive （23.3%） （P〉0.05）; 4 were HCV positive （13.3%） （P〈0.05）; no samples was HBV ＋ HCV co-infected positive （ P 〉 0. 05 ）. Conclusions ： Patients who were infected HIV by blood transfu- sion could be infected HCV at the same time. When the persons were treated for anti-HIV medicine, they would be checked up HBV and HCV. If the HIV patients are HBV and/or HCV positive, they would be treated by anti HBV and/or HCV medicine, too.

关 键 词：艾滋病 病毒载量 聚合酶链式反应 乙型肝炎病毒 丙型肝炎病毒 

分 类 号：R512.91[医药卫生—内科学]