^(99m)锝-甲氧基异丁基异腈显像在乳腺良恶性肿块鉴别诊断中的应用  

^(99m)Tc-MIBI imaging in diagnosis breast begign and malignant tumor

作　　者：杨晓君[1] 余建军[2] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2009年第5期413-414,共2页Ningxia Medical Journal

摘　　要：目的探讨99m锝-甲氧基异丁基异腈(99mTc-MIBI)显像在乳腺良恶性肿块鉴别诊断中的应用价值。方法对30例乳腺肿块患者行99mTc-MIBI乳腺显像,经病变乳腺对侧肘静脉注射显影剂99mTc-MIBI740MBq后20-30min,行乳腺正前位,左、右侧位平面显像。计算乳房肿瘤与健侧对应部位的放射性比值(T/N)。乳房内出现异常放射性浓聚,T/N比值>1.2为阳性,并与穿刺组织学病检或者术后病检结果对照。结果15例乳腺良性病变患者99mTc-MIBI显像阴性者13例,阳性者2例,15例乳腺恶性肿瘤患者99mTc-MIBI显像阳性者14例,阴性者1例。乳腺癌组T/N平均值(1.66±0.81),良性肿瘤T/N平均值(0.65±0.88),P<0.01,两组间差异有统计学意义。99mTc-MIBI显像对乳腺癌诊断的敏感性为93.3%,特异度为86.6%;阳性预测值为87.5%;阴性预测值为92.9%,准确率为90.0%。结论99mTc-MIBI乳腺显像诊断乳腺癌有相当高的准确率,可作为诊断乳腺良恶性肿瘤的方法。Objective To evaluate the clinical value of ^99mTc -MIBI imaging in diagnosis breast begign ang malignant. Methods ^99mTc - MIBI scintimammography were performed in 30 women with palpable breast lesions. Two lateral views and one anterior planar view were obtained 20 - 30 min after intravenous injection of 20 mic ^99mTc - MIBI. The T/N radio of the average counts in the tumor over the average counts in the contral alteral ROI was calculated, Comprarative diagnosis was done by postoperative or biopsy pathology in all cases. Results Of the 30 cases, there were 14 true -positive, 1 false -negtive in 15 malignants imaging and 13 true- negative and 2 false -positive inl5 benign. The sensitivity of ^99mTc - MIBI images in diagnosis of breast cancer was 93.3% ,and the specificity was 86.6%. the accuracy was 90.0%. Conclusion ^99mTc - MIBI scintigraphy of breast lesions is an effective means of differentiating benign from malignant lesions.

关 键 词：99m锝-甲氧基异丁基异腈 乳腺癌 放射性核素显像 

分 类 号：R817.4[医药卫生—影像医学与核医学]