生远志及其皂苷与蜜远志对大鼠胃黏膜ITF、α-TGF表达的影响  

Studies on the Influence of Crude and Honey-Stir-Baked Radix Polygalae on Expression of α-TGF and ITF of Rat Gastric Mucosa

作　　者：刘贤武[1] 李德华 肖武[1] 王建[1] 

机构地区：[1]成都中医药大学药学院,四川成都610075 [2]成都地奥集团,四川成都610041

出　　处：《四川省卫生管理干部学院学报》2009年第1期1-3,共3页Journal of Sichuan Continuing Education College of Medical Sciences

基　　金：国家自然科学基金资助课题:蜜制降低生远志胃肠毒性物质基础及其作用机理研究(No30371778)

摘　　要：目的:阐明蜜炙远志降低胃粘膜损伤的生物学机理,拟从分子水平揭示中药炮制降低胃肠毒性的科学内涵。方法:采用RT-PCR法考察大鼠胃粘膜转化生长因子α(α-TGF)、肠三叶因子(ITF)表达水平。结果:蜜远志能显著增强大鼠胃粘膜ITF的表达(P<0.05),并能上调胃粘膜α-TGF基因表达,生远志对其无显著影响。结论:蜜炙远志降低粘膜损伤的机理可能与增强胃粘膜肠ITF、α-TGF的表达,增强对胃粘膜的保护和损伤修复等机制有关。Objective： To study the biological mechanism of reducing the gastric mueosa damage by honey-fried Radix Polygalae, and reveal the scientific connotation of gastric and intestine toxicity reducing by concocted Traditional Chinese Medicine at molecular level.Methods： To determine the expression amount of α-TGF and ITF by RT-PCR. Results： Honey-stir-baked Radix Polygalae significandy increased the expression of α-TGF and ITF （ P 〈 0.05）, but crud Polygalae didn＇ t. Conclusion： The biological mechanism may be related to increase α-TGF and ITF expression, which would promote the protection to gastric mucosa and xepair.

关 键 词：生远志 蜜远志 胃粘膜 机制 

分 类 号：R96[医药卫生—药理学]