益气活血解毒汤对动脉粥样硬化模型家兔血脂、血液流变学、同型半胱氨酸的影响  

Yiqi Huoxue Jiedu decoction on serum lipid,hemorheology and homocysteine in rabbits with atherosclerosis

作　　者：丁树根[1] 李忠志[2] 胡业彬[2] 谢强龙[1] 杨明[2] 王东[2] 

机构地区：[1]安徽中医学院 [2]安徽省中医院,安徽合肥230038

出　　处：《山东中医药大学学报》2009年第3期253-254,共2页Journal of Shandong University of Traditional Chinese Medicine

基　　金：安徽省教育厅自然科学基金项目(编号:2006KJ340B)

摘　　要：目的:观察益气活血解毒汤对实验性动脉粥样硬化家兔血脂、血液流变学、同型半胱氨酸的影响。方法:将家兔随机分为4组即空白对照组、模型对照组、益气活血解毒汤组及血脂康组,采用高脂饮食复制动脉粥样硬化家兔模型,10周后测定家兔各项指标。结果:益气活血解毒汤组与模型对照组比较各血脂指标有显著性差异(P<0.01),益气活血解毒汤组血液流变学、同型半胱氨酸指标明显低于模型对照组(P<0.01或P<0.05)。结论:益气活血解毒汤可通过调节血脂、改善家兔血液流变状态和降低血清同型半胱氨酸含量,对动脉粥样硬化家兔产生良好的治疗作用。Objective： To investigate the effect of Yiqi Huoxue Jiedu decoction on serum lipid, hemorheology and homocysteine（Hcy） in rabbits with atherosclerosis. Methods： Rabbits were randomly divided into four groups： control group, model group, Yiqi Huoxue Jiedu decoction group and Xuezhikang group. The above indexes of rabbits were determined after ten weeks. Results： The serum lipid index in Yiqi Huoxue Jiedu decoction group was obvious difference from that of the model group（P〈0.01）. The hemorheology and homocysteine index in Yiqi Huoxue Jiedu decoction group were obviously lower than those in the model group（P〈0.01 或 P〈0.05）. Conclusion： Yiqi Huoxue Jiedu decoction had good therapeutical effect by accommodating the level of serum lipid and improving of hemorheology and homocysteine in rabbits with atherosclerosis.

关 键 词：益气活血解毒汤 动脉粥样硬化 血脂 血液流变学 同型半胱氨酸 家兔 实验研究 

分 类 号：R285.5[医药卫生—中药学]