白刺花茎叶抗炎抗过敏作用的实验研究  

An Experimental Study on the Anti-Inflammatory and Anti-Allergic Effect of Sophora Davidii Stems and Leaves

作　　者：毛晓健[1] 李金艳[1] 却翎[1] 

机构地区：[1]云南中医学院,云南昆明650200

出　　处：《云南中医中药杂志》2009年第5期53-54,共2页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：植物化学与西部植物资源持续利用国家重点实验室开放基金资助项目(编号:P200413)

摘　　要：目的:对白刺花茎叶进行抗炎、抗过敏的实验研究并与花作比较。方法:抗炎实验采用二甲苯所致的小鼠耳肿胀的方法,二甲苯所致小鼠皮肤毛细血管通透性增高以及角叉菜胶所致小鼠足趾肿胀的实验方法;抗过敏实验采用DNCB(2.4-二硝基氯苯)所致小鼠DTH(迟发性过敏反应)以及右旋糖酐所致小鼠皮肤瘙痒等实验方法。结果:白刺花的茎叶和花对小鼠的耳肿胀,足趾肿胀有一定的抑制作用,同时可以降低小鼠毛细血管的通透性;对DNCB所致小鼠DTH影响不明显,还可以减少小鼠的瘙痒次数及瘙痒持续时间。结论:白刺花茎叶有一定的抗炎、抗过敏作用,但效果均不如花,由于茎叶的产量大,容易采集,对其化学成分和各种成分药效学有待进一步研究。Purpose: To study the anti-inflammatory and anti-allergic effect of Sophora Davidii stems and leaves.Methods: The anti-inflammatory experiment was made to induce test mouse ears swelling by xylene which caused the increase of capillary permeability of the mouse skin,and to cause the mouse toes swelling by carrageenan.The anti-allergic experiment was made to induce the DTH of the mice(delayed type hypersensitivity) by DNCB(2.4-b nitrochlorobenzene) and the skin itching of the mice by dextran.Results: Sophora Davidii stems and leaves and flowers had certain inhibiting effect on the ear and toe swelling of the mice and at the same time could reduce the capillary permeability of the mice,and decrease the number and the duration of the mice itching,but showed insidious effect on the DTH of the DNCB-induced mice.Conclusion: Sophora Davidii stems and leaves have certain anti-inflammatory and anti-allergic effect,but not as effective as its flower.As the stem and leaf are in mass production,and easy to collect Its chemical composition and various pharmacodynamic components are expected to be studied further.

关 键 词：白刺花 茎叶 花 抗炎 抗过敏 实验研究 

分 类 号：R285.5[医药卫生—中药学]