转化生长因子β与胸膜纤维化  

Transforming growth factor-β and pleural fibrosis

作　　者：祝清清[1] 孙耕耘[1] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科,合肥230022

出　　处：《国际呼吸杂志》2009年第10期609-612,共4页International Journal of Respiration

摘　　要：胸膜纤维化是临床常见病理过程。在胸膜炎症中需防止胸膜纤维化的发生，而在胸膜固定术中常诱导胸膜纤维化。转化生长因子β是胸膜纤维化发病机制中重要细胞因子之一。近来的研究表明转化生长因子β及其抑制剂在胸膜疾病的治疗中发挥重要作用。本文就转化生长因子β在胸膜腔内的来源、胸膜纤维化发生机制和治疗中的应用作一综述。Pleural fibrosis is a common clinical pathological process. Pleural fibrosis is undesirable outcome in pleuraI infection, however, successful induction of pleural fibrosis is the basis of therapeutic pleurodesis. Transforming growth factor-β（TGF-β） is a key mediator in the pathogenesis of pleural fibrosis. Recent findings have demonstrated the therapeutic potential of both TGF-β and its inhibitors. This paper reviews the sources of TGF-β in the pleural cavity and the pathogenesis and treatment of pleural fibrosis.

关 键 词：胸膜 纤维化 转化生长因子Β 

分 类 号：R5[医药卫生—内科学]