低氧诱导因子1与低氧性肺损伤的研究进展  

Relationship between hypoxia inducible factor-1 and hypoxic lung injury

作　　者：蒋云燕[1] 谢敏[1] 

机构地区：[1]四川大学华西医院呼吸内科,成都610041

出　　处：《国际呼吸杂志》2009年第10期626-629,共4页International Journal of Respiration

摘　　要：低氧诱导因子1是细胞在低氧条件下产生的具有转录活性的核蛋白，在低氧应答反应中起核心作用，能调节100多种涉及低氧应激下细胞适应和存活的靶基因。近年来，低氧诱导因子1在低氧性肺损伤中的作用也逐渐受到人们的关注。该文就低氧诱导因子1的生物学特点、对靶基因的调节及在低氧性肺损伤中的作用作一综述。Hypoxia inducible factor-1（HIF-1） is a nucleoprotein with transcriptional activity produced by ceils under hypoxic condition,which plays a crucial role in cellular response to stress of hypoxia. HIF-1 modulates the expression of more than 100 genes involved in cellular adaptation and survival under hypoxic stress. In recent years,more attention has been paid to the role of HIF-1 in hypoxic lung injury. This article makes a summary on the biological characteristics of HIF-1 and adjustment to the target genes and its effect on hypoxic lung injury.

关 键 词：低氧 低氧诱导因子1 肺损伤 

分 类 号：R563[医药卫生—呼吸系统]