重度颅脑损伤并发应激性溃疡出血的机制及治疗  

Pathogenesis and therapy of severe craniocerebral injury patients complicated with stress ulcer bleeding

作　　者：周祥[1] 张洪涛[2] 袁国艳[1] 赵新利[1] 金保哲[1] 惠磊[1] 周文科[1] 史耀亭[1] 

机构地区：[1]新乡医学院第一附属医院神经外科,卫辉453100 [2]新乡医学院,新乡453000

出　　处：《中国实用神经疾病杂志》2009年第8期22-24,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的通过对89例重度颅脑损伤并发应激性溃疡患者的治疗方法进行回顾性分析,探讨重度颅脑损伤并发应激性溃疡出血的机制及治疗方法。方法积极治疗原发病及并发症,加强对症支持治疗,早期留置胃管、鼻饲,静脉应用质子泵抑制剂,局部应用胃黏膜保护剂。结果75例临床治愈,14例死亡,病死率约15.7%。结论重度颅脑损伤并发应激性溃疡出血,病死率高,应早预防、早发现、早治疗。Objective To explore the pathogenesis and therapy of severe craniocerebral injury patients complicated with stress ulcer bleeding through analysis of the treatment of 89 cases retrospectively. Methods The treatment included treating the primary disease and complications actively, enhancing the supportive treatment, indwelling feeding tube and nasal feeding early, applying the proton pump inhibitor by intravenous injection,and applying the gastric mucosal protectant locally. Results Seventy five cases were cured, 14 cases died, the death rate was about 15.7%. Conclusion Severe craniocerebral injury patients complicated with stress ulcer bleeding had high death rate, and should be early prevention, discovery and treatment.

关 键 词：重度颅脑损伤 应激性溃疡出血 机制 治疗 

分 类 号：R651.15[医药卫生—外科学]