硝酸异山梨醇酯与硝普钠治疗高血压急症的对比研究  被引量:1

Comparing research of treating hypertensive emergency with isosorbide nitrate and sodium nitroprusside

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作  者:郭仁永[1] 李玲[1] 殷明君[2] 

机构地区:[1]南阳医学高等专科学校,南阳473058 [2]河南南阳市第一人民医院心内科,南阳473000

出  处:《中国实用神经疾病杂志》2009年第9期9-11,共3页Chinese Journal of Practical Nervous Diseases

摘  要:目的比较硝酸异山梨醇酯与硝普钠治疗高血压急症的临床实用价值。方法对66例高血压急症患者随机分为2组,其中33例应用硝酸异山梨醇酯50mg加入5%葡萄糖500ml中,以100~300μg/min速度静滴;33例应用硝普钠50mg加入5%葡萄糖500ml中,以20~260μg/min速度静滴,均根据血压调整滴速,比较2组间用药特点、降压疗效及不良反应等指标。结果2组间有效率均为100%,但在药物的配制、使用方法、血流动力学监测及不良反应的发生方面有显著差异。结论硝酸异山梨醇酯是一个可替代硝普钠治疗高血压急症的高效、安全、使用方便的紧急降压药物。Objective To compared the clinical practice value of isosorbide nitrate with sodium nitroprusside in treating hy- pertensive emergency. Methods Sixty-six patients with hypertensive emergency were randomly divided into 2 groups . Thirtythree cases were treated with isosorbide nitrate 50rag plus 5 % glucose solution 500ml, 100~300μg/min,iv gtt. Thirty-three cases were treated with sodium nitroprusside,50mg plus 5% glucose solution 500ml, 20-260μg/min,iv gtt. According to blood pressure level,administration rate was controlled. Administration character,effect and adverse reaction between 2 groups were compared. Results Effective rates between 2 groups were all 100%. However, there were remarkable differences in drug preparation, use method,hemodynamic monitor and adverse reaction occurrence. Conclusion Isosorbide nitrate is a drug of acutely lowering blood pressure, with high effect, safety, convenient administration, and can take place of sodium nitroprusside in treating hypertensive emergency.

关 键 词:硝酸异山梨醇酯 硝普钠 高血压急症 

分 类 号:R544.1[医药卫生—心血管疾病]

 

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