H5N1禽流感病毒感染雏鸭的病理学观察  

Pathological observation of ducklings infected with H5N1 avian influenza virus

作　　者：田伟[1] 吕晓萍[1] 马宏伟[1] 郑世民[1] 刘明[2] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030 [2]中国农业科学院哈尔滨兽医研究所,黑龙江哈尔滨150001

出　　处：《中国兽医科学》2009年第5期445-448,共4页Chinese Veterinary Science

基　　金：国家自然科学基金项目(30371066);黑龙江省教育厅项目(11511031)

摘　　要：通过眼观病变观察和组织病理学检查方法对H5N1禽流感病毒感染雏鸭的各器官组织病理变化进行了系统的研究,为H5N1禽流感病毒致病机制的研究及禽流感的临床诊断提供理论依据。结果显示,雏鸭感染H5N1禽流感病毒后,除机体出现临床症状外,主要呈现明显的神经症状;病理剖检发现胰腺、肝、脾肿大,并见大小不一、数量不等的坏死灶;组织病理学检查发现全身各器官组织呈现出血、坏死和淋巴细胞浸润。经分析,多器官发生明显的细胞变性、坏死很可能是H5N1亚型禽流感病毒致病性的重要表现形式之一。In order to provide the theoretical evidence for the pathogenic mechanism and clinical diagnosis of HSN1 avian influenza virus（AIV）,the gross and pathological lesions caused by HSN1 AIV were observed in ducklings based on the traditional method of pathology. The results showed that the ducklings infected with the HSN1 AIV exhibited obviously neurological symptoms. At necropsy, the most common lesions including multifocal necrosis and edema in the pancreas, spleen and liver were found. The necrosis, hemorrhage and lymphocytic infiltration were also observed in the internal organs. It was believed that cell degeneration and necrosis in many organs might be one of the important manifestations of the pathogenicity of HSN1 AIV.

关 键 词：H5N1禽流感病毒 雏鸭 病理变化 

分 类 号：S852.659.5[农业科学—基础兽医学]