一起人感染高致病性禽流感(H5N1)家庭聚集性病例的流行病学调查  

EPIDEMIOLOGICAL INVESTIGATION OF A FAMILY CLUSTER OF HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS INFECTION (H5N1)

作　　者：陆小军[1] 祖荣强[2] 洪镭[1] 史薇 田秀梅 李解权[1] 

机构地区：[1]南京市疾病预防控制中心,江苏210003 [2]江苏省疾病预防控制中心 [3]鼓楼区疾病预防控制中心 [4]玄武区疾病预防控制中心

出　　处：《现代预防医学》2009年第10期1823-1826,共4页Modern Preventive Medicine

摘　　要：[目的]为明确两名禽流感病例的感染来源,探索病例间是否存在人与人之间的传播,总结禽流感防控工作的经验及教训,并提供科学依据。[方法]通过现场流行病学调查,按照《人感染高致病性禽流感应急预案》的要求,开展病例诊断、报告、疫情调查和控制工作。[结果]共发生两例H5N1确认病例,系父子关系。首例病例感染来源不明,在发病后d8抢救无效死亡。第2例痊愈出院,其感染来源最大可能是在医院内护理首例病例期间,与其近距离接触感染。[结论]此起疫情是我国大陆第一起确诊的家庭聚集性人禽流感H5N1发病。提高不明原因肺炎监测系统的敏感性,加强对密切接触者特别是直系亲属的管理是及早发现病例、提高救治率和控制疫情的关键措施。[Objective] To investigate the infection source of two patients infected With avian influenza virus （H5N1）,and to explore if there is person-to.person transmission as well as summarize experience so as to provide scientific reference for prevention and control. [Methods ] According to ,emergency plan on highly pathogenic avian influenza virus infection, case diagnoses and report, epidemic investigation and Control work were conducted by using field epidemiological investigation metheds. [Results] The relationship of two confirmed patients infected with H5N1 is parent child relation. The infection source was unclear, and the first case with H5N1 found died after 8 days. The second ease were cured and had discharged, the main infection source for him might be close contact infection during the nursing of the first patient. [ Conclusion ] It is the first family cluster Of H5N1 infection in China's Mainland： Improving the sensitivity of the surveillance system of unknown cause pneumonia and strengthening the management for close contact especially for the blood-related family members were key measures to early detection, treatment method for control the epidemic of H5N1.

关 键 词：人感染高致病性禽流感 家庭聚集性 流行病学 

分 类 号：R373.13[医药卫生—病原生物学]