正已烷引起多发性周围神经早期损伤指标的研究  

STUDY ON THE EARLY INJURED INDEXES OF WORKERS WITH SURROUNDINGS NERVE INDUCED BY N-HEXANE

作　　者：肖全华[1] 林琳[1] 邝云洪 何丽英[1] 于碧鲲[1] 梁宁 俞培禹[1] 谢万力 

机构地区：[1]深圳市龙岗区疾病预防控制中心,深圳518172 [2]深圳市龙岗区布吉预防保健所 [3]深圳市龙岗区横岗预防保健康所 [4]广东省卫生监督所

出　　处：《现代预防医学》2009年第10期1836-1838,共3页Modern Preventive Medicine

摘　　要：[目的]通过对正己烷作业工人的情感状态和神经行为功能的调查,探讨正已烷对作业工人周围神经早期损伤的指标。[方法]采用WHO推荐的神经行为核心测试组合(NCTB)和SCL-90症状自评量表,对82名正己烷作业工人进行神经行为功能和情感状态测试;用气相色谱氢火焰离子化法测定作业工人尿中2,5-己二酮浓度。[结果]在进行两组相关调查测试指标的比较中,情感状态测试接触组的总分(t=2.60,P﹤0.05)、阳性症状得分(t=2.76,P﹤0.01)和躯体化(t=3.70,P﹤0.01)、抑郁(t=2.84,P﹤0.01)、焦虑(t=2.55,P﹤0.05)等因子得分高于对照组;与全国常模比较,接触组躯体化(t=5.36,P﹤0.01)、焦虑(t=4.02,P﹤0.01)、抑郁(t=2.03,P﹤0.05)等因子得分高于全国常模;在神经行为功能测试中接触组的平均反应时(t=5.16,P﹤0.01)、手提转捷度的利手(t=3.91,P﹤0.01)和非利手(t=2.31,P﹤0.05)、目标追踪测试的正确打点数(t=2.30,P﹤0.05)和错误打点数(t=2.80,P﹤0.01)及总和(t=2.11,P﹤0.05)等测试结果与对照组比较差异具有统计学意义。[结论]正己烷对作业工人的情感状态和周围神经行为功能可能产生一定的影响。[Objective ] To explore the injured indexes of workers with surroundings nerve induced by N-hexane with investigation of the emotion appearance and neurobehavioral function of workers exposed to N-hexane. [ Methods] The emotion appearance and neurobehavioral function of 82 workers exposed to N-hexane were investigated by WHO neurobehavioral core test battery （NCTB） and SCL-90; the concentration of 2, 5-hexanedione in the urines was tested by Gas chromatography Flame Ionization Detector. [ Results ] During the injured indexes, aggregate score （t = 2.60, P 〈 0.05）, the scores of positive symptom （t = 2.76, P〈 0.01） and the scores of body （t = 3.70, P〈 0.01）, depression （t = 2.84, P〈 0.01）, anxious （t =2.55, P 〈 0.05） in the workers exposed to N-hexane showed significant higher than the national normal. The scores of body （t= 5.36, P 〈 0.01 ）, anxiety （t = 4.02, P 〈 0.01） and depression （t = 2.;3, P 〈 0.05） in workers exposed to N-hexane were significantly higher than the national normal. During the nerve behavior test, the simple reaction time （t = 5.16, P 〈 0.01）,manual dexterity （t = 3.91, P 〈 0.01 ） and aiming test （t = 2.11, P 〈 0.05） showed a Significant difference between the exposure group and the control group. [Conclusion] N-hexane has certain effect on the emotion appearance and neurobehavioral function of workers contacted N-hexane.

关 键 词：正己烷:神经行为功能 SCL-90症状自评量表 2 5-己二酮 

分 类 号：R722.144[医药卫生—儿科]