连续5年临床分离凝固酶阴性葡萄球菌的耐药变迁  

CHANGES OF ANTIMICROBIAL RESISTANCE AMONG COAGULASE NEGATIVE STAPHYLOCOCCUS ISOLATED IN RECENT 5 YEARS

作　　者：许建成[1] 周琪[1] 刘韶晖[1] 黄晶[1] 

机构地区：[1]吉林大学第一医院,长春130021

出　　处：《现代预防医学》2009年第10期1925-1926,1931,共3页Modern Preventive Medicine

基　　金：吉林省卫生厅重点实验室科研课题(编号:200640)

摘　　要：[目的]了解近5年来我院凝固酶阴性葡萄球菌的耐药变迁。[方法]采用纸片扩散法进行药敏试验,根据美国临床实验室标准化研究所(CLSI)文件的标准判断结果;采用WHONET-5软件对耐药性数据进行分析。[结果]2003～2007年我院收集凝固酶阴性葡萄球菌1167株,来自血液、分泌物、尿液、脓液者分别占37.7%、26.0%、12.6%、10.4%。耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率一直高于80.0%,凝固酶阴性葡萄球菌多重耐药严重,临床常用抗菌药物的耐药性呈逐年上升趋势。[结论]加强凝固酶阴性葡萄球菌细菌耐药监测,了解其耐药变迁,指导临床合理用药,防止耐药菌株的传播。[ Objective] To investigate the antimierobial resistance of coagulase negative Staphylococcus isolated in the recent 5 years. [Methods] Disk dilt＇usion test was used to study the antimicrobial resistance. The results were evaluated based on Clinical and Laboratory Standards Institute. WHONET 5 was applied to analyze the drug resistance. [Results] 1167 strains of eoagulase negative Staphylococcus were mainly collected from bloat （37.7%）, secretions （26.0%）, urine （12.6%） and abscesses （10.4%） during the past 5 years. The detection rate of MRCNS in coagulase negative Staphylococcus was high than 80.0% in the recent 5 years. Susceptibility test showed that coagulase negative Staphylococcus was muhiple resistant. The antimicrobial resistance of coagulase negative Staphylococcus has increased in recent 5 years. [ Conclusion] It is neecssary to strengthen monitoring on the antimicrobial resistance to coagulase negative Staphylococcus. The change of the antimicrobial resistance should be investigated in order to direct rational drag utilization in clinic and prevent the transmission of drug-resistant bacterial.

关 键 词：凝固酶阴性葡萄球菌 耐甲氧西林凝固酶阴性葡萄球菌 抗药性 微生物 微生物敏感试验 药物监测 

分 类 号：R378.11[医药卫生—病原生物学]