雷莫司琼和托烷司琼预防术后镇痛患者恶心呕吐的疗效观察  

The clinical observation of ramosetron and tropisetron in the prevention of nausea and vomiting in patients with postoperative analyesia

作　　者：文公堂[1] 周菊[1] 刘刚[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院麻醉科,233004

出　　处：《临床合理用药杂志》2009年第8期9-10,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较雷莫司琼和托烷司琼预防术后镇痛患者恶心呕吐的预防作用。方法选择120例ASAⅠ～Ⅱ级择期子宫切除术患者,随机将患者分为3组,在开始缝皮前静脉注射雷莫司琼(R组,n=40)0.3mg、托烷司琼(T组,n=40)5mg、生理盐水(对照组,C组,n=40)5ml。观察术后48h内恶心呕吐发生情况并作比较。结果在术后24h内和48h内恶心呕吐的发生率R组(17.5%、32.5%)和T组(15.0%、30.0%)明显低于C组(40.0%、67.5%),差异有统计学意义(P<0.01),R组和T组比较差异无统计学意义(P>0.05)。结论雷莫司琼和托烷司琼均可显著减少术后恶心呕吐发生率,对于预防恶心呕吐两者疗效相当。Objective To compare the ramosetron tropisetron and the prevention of postoperative analgesia for the prevention of nausea and vomiting in patients with the role. Methods 120 cases of ASA Ⅰ - Ⅱ grade selective hysterectomy patients were randomly divided into three groups of patients, at the beginning of skin suture ramosetron former intravenous （R group, n =40） 0.3mg, tropisetron （T group, n = 40） 5mg, normal saline （control group, C group, n = 40） 5ml. Observed within 48h ＇after the occurrence of nausea and vomiting and for comparison. Results After 24 hours and 48 hours, the incidence of nausea and vomiting R group （ 17.5%, 32.5% ） and the T group （ 15.0%, 30.0% ） significantly lower than C group （40.0%, 67.5 % ;P 〈 0.01 ）, R group and T group had no significant statistical difference （ P 〉 0.05 ）. Conclusion Ramosetron and tropisetron can significantly reduce the incidence of postoperative nausea and vomiting,and there is not differenet in the prevention of nausea and vomiting.

关 键 词：恶心 呕吐 子宫切除术 雷莫司琼 托烷司琼 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]