序贯法研究甘草酸二铵对小鼠镇咳作用  

Sequential study on the antitussive effect of diammonium glycyrrhizinate on mice

作　　者：刘宾[1] 江南[1] 

机构地区：[1]湖北中医学院药学院,湖北武汉430065

出　　处：《中国医院药学杂志》2009年第10期820-822,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:序贯法研究甘草酸二铵镇咳作用,为临床用药提供理论依据。方法:采用"序贯法"实验,作用于不同组别的小鼠求得各组的EDT50,依次定量判断甘草酸二铵的有关镇咳活性,并通过求得样品组与对照组EDT50相对值R使各样品的相互对比有了客观的数值。结果:体质量为18～22g的中号鼠的EDT50为24.1;甘草酸二铵预先给药,EDT50增大,EDT50较空白组有所延长。结论:甘草酸二铵高剂量的EDT50比低剂量的EDT50延长,随着剂量的增加,镇咳效果增强。OBJECTIVE To study the antitussive effect of diammonium glycyrrhizinate. METHODS Sequential method was adopted. EDT50 value was obtained for quantitative evaluation of the effect. RESULTS EDT50, of the mice of 18-22 g was 24. 1, EDT50, increased with the pre-adminnistratin of the gtycyrrhizinate. CONCLUSION The EDT50, of high dose glycyrrhizinate was prolonged compared with the low dose.

关 键 词：咳嗽 小鼠 甘草酸二铵 镇咳作用 EDT50 

分 类 号：R971[医药卫生—药品]