二硫化碳对接触男工性腺激素及生精功能的影响  

The effects of carbon disulfide (CS_2) on gonadotropins and spermatogenesis in workers exposed to CS_2

作　　者：邓丽霞[1] 郑履康[1] 刘力[1] 张桥[1] 

机构地区：[1]中山医科大学劳动卫生与职业病学教研室

出　　处：《职业医学》1998年第1期6-7,共2页China Occupational Medicine

基　　金：中华医学基金会(CMB)资助

摘　　要：本文旨在观察二硫化碳（ＣＳ２）对接触工人促性腺激素和生精功能的影响。工人工作地点ＣＳ２平均浓度（几何均数）为３２．６０±５．１４ｍｇ／ｍ３，约高于国家容许浓度２倍，对１８例长期接触超标浓度的ＣＳ２作业工人进行了血清睾酮（Ｔ），促黄体生成素（ＬＨ），间质细胞刺激素（ＦＳＨ）测定，观察１６名工人精液的某些参数。结果表明：ＣＳ２接触组血清中ＬＨ和ＦＳＨ浓度与对照组比较，显著升高，Ｐ＜０．０１；而ＣＳ２组精子计数、血清Ｔ浓度与对照组相比，明显降低，Ｐ＜０．０５。畸形率高于对照组，但无统计学意义，本研究结果表明，ＣＳ２对接触工人性腺内分泌功能已造成一定的损伤，并降低生精功能。The effect of carbon disulfide on gonadotropins and the spermatogenesis in workers exposed to CS_2 was studiedThe mean concentration of CS_2 in workplace was 32.60±5.14mg/m3,which was 3 fold higher than the maximal allowance concentration of national standardThe serum testosterone(T)、follicle stimulating hormone(FSH) and luteinizing hormone(LH) in 18 workers and some parameters of semen in 16 workers were measuredThe results showed:serum T level in CS2 group(1748±341mmol/L) was significantly lower than that of control (2307±551mmol/L),P<005In addition,LH(829±123IU/L)、FSH(752±281IU/L) in CS2 group were significantly higher than those in control,which were 559±086IU/L and 395±109IU/L respectively,P<001Sperm count in workers of CS2 group was decreased when compared with that of control,P<005The frequency of abnormal sperms in morphology was higher than that of control,but there was no statistical significanceThe results suggested that both the endocrine functions and gonad organ were disturbed in workers exposed to higher level of CS2,consequestly the spermatogenesis was decreased

关 键 词：性腺激素 生精 二硫化碳 工人 

分 类 号：R135.14[医药卫生—劳动卫生]