实验性铍肺的病理形态学观察  

Pulmonary histopathological study of experimental beryllium lung

作　　者：李学军[1] 丁丽华[1] 刘镜愉[1] 赵蕊[2] 

机构地区：[1]北京医科大学第三医院职业病科 [2]北京医科大学第三医院中心实验室

出　　处：《职业医学》1998年第1期8-10,共3页China Occupational Medicine

摘　　要：采用氧化铍一次性气管内注入染毒的方法制备豚鼠铍病模型。肺组织病理观察显示，染毒早期病变为呼吸系统化学性炎症，表现为支气管炎、肺炎及肺水肿。后期以淋巴细胞、上皮样细胞和多核巨细胞肉芽肿病变明显。电镜观察见铍病豚鼠肺泡间隔增宽，偶见胶原增生，肺泡Ⅱ型细胞增生，其细胞内板层体亦增多。Suspension of BeO in sterile NS(10g/L) 1ml was injected endotracheally in guinea pigsThe pulmonary histopathological observation was taken week by weekThe light microscope showed that a chemical bronchitis and pneumonia were developed in early stage,and granulomatous disease composed by lymphocyles,epithelioid cells and multinucleated giant cells was formed in late stage after BeO endolracheal injectionThe electronic microscope showed the thickening of interalveolar septa with multiple collagens;hyperplasia of type Ⅱ cells and increase of lamella bodies were also shown

关 键 词：铍病 动物模型 病理形态学 职业病 

分 类 号：R135.1[医药卫生—劳动卫生]