通脉降脂口服液防治冠状动脉粥样硬化性心脏病的临床观察  

Clinical Observation on Preventing and Treating Coronary Atherosclerotic Hear Disease with Tongmai Jiangzhi Oral Liquid

作　　者：张铁忠[1] 张久亮[1] 吕崇山[1] 李海聪[1] 毛建生[1] 史载祥[1] 鞠建伟 

机构地区：[1]中日友好医院中医心肾科,北京100029 [2]山东烟台毓磺顶医院

出　　处：《中国中西医结合杂志》1998年第2期77-80,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家八五攻关课题资助

摘　　要：观察中药复方通脉降脂口服液降低血脂、减轻自由基损伤、调整前列腺素代谢、治疗冠心病心绞痛的临床疗效。方法：治疗组４１例、对照组 ２４例冠心病心绞痛伴高脂血症患者分别口服通脉降脂口服液及月见草油胶丸各１个月，进行临床观察，并观察治疗前后血脂、载脂蛋白（ａｐｏ）、血浆丙二醛（ＭＤＡ）、全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、血栓素Ｂ_２（ＴＸＢ_２）、６－酮－前列腺素Ｆ_１α。（６－ｋｅｔｏ－ＰＧＦ_１α）等的变化。结果：治疗组患者心绞痛的总有效率为８７．８０％，心电图总有效率为５０．００％，血清总胆固醇、甘油三酯、 ａｐｏＢ、 ＭＤＡ、 ＴＸＢ_２　 ＴＸＢ_２／６－ｋｅ－ｔｏ－ＰＧＦ_１α均较服药前明显降低（ Ｐ＜ ０． ００１），而血清高密度脂蛋白胆固醇、 ａｐｏＡ_１，全血ＧＳＨ－Ｐｘ及ａｐｏＡ_１／ａｐｏＢ比值明显升高（Ｐ＜０．０５～Ｐ＜０．００１）。结论：通脉降脂口服液可有效地降低血脂、阻止动脉粥样硬化、治疗冠心病，从而为临床防治动脉粥样硬化提供有效的复方中药制剂。To observe the clinical effect of Tongmai Jiangzhi Oral Liquid (TJOL) on blood lipid, lipid peroxidation, prostaglandin metabolism in treating coronary heart disease and angina pectoris with hyperlipidemia. Methods: Forty-one cases in treated group and 24 in control group were treated with TJOL and Capsulae Oenoth Erae Biennisolei (COEB) for one month respectively. Serum lipid, apolipoprotein, plasma malonyldialdehyde (MDA), superokide dismutase (an), thromboxane B_2(TXB_2), 6-keto-prostaglandin F_1α and blood glutathione peroxidase (GSH-Px) were measured before and after treatment. Results: After treatment with TJOL, the total effective rate was 87.80% in relieving angina and 50.00% in improving ECG. Other data showed that the levels of serum TC, TG, apoB, plasma MDA, TXB_2 and TXB_2/6-keto prostaglandin F_1α ratio lowered and levels of apoA, GSH-Px, serum HDL-C, apoA_1/apoB increased (P<0.05～P<0.001). Conclusions: TJOL could effectively lower blood lipid, reduce injury caused by free radicals, regulate prostaglandin metabolism and treat coronary heart disease. By this study, an effective prescription of Chinese herbal medicine was offered for prevention and treatment of coronary heart disease.

关 键 词：冠心病 通脉降脂口服液 防治 

分 类 号：R259.414[医药卫生—中西医结合]