小鼠大脑皮质和海马结构内胆碱能纤维的分布及增龄变化  

The aging changes of the distribution of cholinergic fibers in mosre cerebral cortex and hippocampal structures in mice

作　　者：舒先涛 陈运才[2] 

机构地区：[1]湖北省职工医学院解剖学教研室 [2]北京医科大学解剖学系

出　　处：《中国老年学杂志》1998年第1期36-38,共3页Chinese Journal of Gerontology

摘　　要：用乙酰胆碱酯酶（ＡＣｈＥ）组织化学方法和体视学测量技术，研究胆碱能纤维在小鼠大脑皮质和海马结构内的分布及增龄变化。结果显示，小鼠大脑皮质和海马结构内ＡＣｈＥ阳性纤维呈不同的板层样分布，老年小鼠（２４月龄）额－顶皮质第Ⅲ、Ⅴ层和海马ＣＡ１、ＣＡ３区分子层及齿状回分子层ＡＣｈＥ阳性纤维密度明显低于成年小鼠（１３月龄）和青年小鼠（３月龄）（Ｐ＜０．０１），后两组间除成年小鼠海马ＣＡ３区分子层纤维密度稍低外，其他各区无显著差异（Ｐ＞０．０５）。结果表明，胆碱能纤维在小鼠大脑皮质和海马结构内的分布具有年龄相关性和区域特异性。おcetylcholinesterase(AChE) histochemical technique and stereological method,were used to investigate the distribution and agerelated changes of cholinergic filbers in the cerebral cortex and hippocampal in C57BL/6 mouse were investigated. The different laminar distribution patterns of AChEpositive fibers were found in teh cerebral cortex and hippocampal structures.The densities of AChEpositive fibers in the Ⅲ、Ⅳ lavers of the frontoparietal cortex,the molecular layers in CA1、CA3 areas and dentate gyrus of the hippocampal were significantly lower in the aged mice. The results indicate that there are agedependent and regionally distinctive cholinergic fiber distribution of cerebral cortex and hippocampus structures in mice.

关 键 词：乙酰胆碱酯酶 大脑皮质 海马 衰老 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]