中国汉族人依赖还原型辅酶Ⅰ/Ⅱ醌氧化还原酶基因多态性  

PRELIMINARY STUDY OF NAD(P)H:QUINONE OXIDOREDUCTASE GENE POLYMORPHISM IN CHINESE POPULATION

作　　者：邵明[1,2] 刘焯霖[1,2] 陈彪 陶恩祥[1,2] 潘锡榜 

机构地区：[1]中山医科大学附属第一医院神经科 [2]美国帕金森病研究所

出　　处：《中山医科大学学报》1998年第1期23-26,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：目的：确定中国汉族人依赖还原型辅酶Ⅰ／Ⅱ［ＮＡＤ（Ｐ）Ｈ：］醌氧化还原酶（ＮＱＯ１）基因ｃＤＮＡ的６０９位点Ｃ→Ｔ（Ｃ６０９→Ｔ）突变的频率分布。方法：利用聚合酶链反应限制性片段长度多态性（ＰＣＲＲＦＬＰ）技术分析了８１名正常中国汉族人ＮＱＯ１基因ｃＤＮＡ的６０９位点的多态性。结果：中国汉族人ＮＱＯ１基因的Ｃ６０９→Ｔ的频率为０４２６；基因型Ｔ６０９／Ｔ６０９、Ｃ６０９／Ｃ６０９与Ｃ６０９／Ｔ６０９的比率分别为０１７、０３２和０５１。结论：该结果提示中国汉族人ＮＱＯ１基因的Ｃ６０９→Ｔ位点的多态性分布规律与西方人有明显的差异。Objective:To confirm the mutation frequency of C609→T in exon 6 of NAD (P)H:quinone oxidoreductase I (NQO1) gene in Chinese population.Methods:The polymorphism of C609→T in exon 6 of NQO1 gene was analyzed in the population of 81 randomly selected Chinese individuals by polymerase chain reaction restriction fragment length polymorphism (PCRRFLP).Results:The frequency of NQO1 C609→T allele was 0426. The index of genotype T609/T609, C609/C609 and C609/T609 were 017 , 032 and 0.51 respectively.Conclusion:The results suggested that the polymorphism of NQO1 C609→T in Chinese individuals is different from the Western individuals significantly.

关 键 词：硫辛酰胺脱氢酶 多态性 依赖还原型 辅酶Ⅰ 汉族 

分 类 号：Q552[生物学—生物化学] Q346.5