快速右心室起搏致心力衰竭犬模型的研制  

A RIGHT VENTRICULAR RAPID PACINGINDUCED CANINE HEART FAILURE MODEL

作　　者：周淑娴[1] 张旭明[1] 伍卫[1] 陈筱潮[1] 张燕[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院心内科

出　　处：《中山医科大学学报》1998年第1期27-30,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：本院科研基金

摘　　要：目的：研究快速右心室起搏致心力衰竭犬模型的临床、血流动力学及心脏病理变化。方法：采用心室内膜电极及起搏器快速起搏（２４０ｍｉｎ－１共４～５周）犬右心室建立心力衰竭模型。结果：快速起搏４～５周后，所有犬均出现明显的充血性心力衰竭表现；平均右房压、右室压、肺动脉压及肺毛细血管楔嵌压明显升高，心输出量、心脏指数及每搏输出量明显下降；病理解剖显示心室腔明显扩大，室壁变薄，光镜检查示心肌细胞水肿、脂肪变性、少数坏死溶解，间质充血、细胞浸润。结论：提示快速右心室起搏致心力衰竭犬模型为较理想的非缺血性全心衰竭模型。Objective:To investigate the changes of the clinical, haemodynamic and cardiac pathological characteristics in experimental canine congestive heart failure (CHF) model induced by rapid right ventricular pacing.Methods:The CHF model was established by rapid right ventricular endocardial pacing (240 min-1) for 4 to 5 weeks. Results:All dogs had clinical conditions of CHF 4 to 5 weeks after rapid right ventricular pacing. There were significant rises in the mean right atrial pressure, right ventricular pressure, pulmonary artery pressure, and pulmonary capillary wedge pressure with significant decreases of cardiac output, cardiac index and stroke volume. The cardiac volume increased and the free wall thickness of ventricle became thin as shown in postmortem examination. Histologic examination of ventricles revealed changes characterized by cardiac cell edema, fatty degeneration, focal cardiac myofiber necrosis, interstitial edema, neutrophils and lymphocytes infiltration and vascular congestion.Conclusion:This right ventricular rapid pacinginduced canine CHF model was an ideal nonischemic CHF animal model.

关 键 词：充血性心力衰竭 疾病模型 起搏 右心室 动物模型 

分 类 号：R541.610.2[医药卫生—心血管疾病] R654.205[医药卫生—内科学]