正常妊娠母体糖代谢状况及胎盘激素水平与胎儿生长的关系  

THE RELATIONSHIP BETWEEN BIRTHWEIGHT, MATERNAL CARBOHYDRATE METABOLISM AND HUMAN PLACENTAL LACTOGEN LEVEL IN NORMAL PREGNANT WOMEN

作　　者：曹筱佩[1] 秦婉文[1] 何哲明[1] 袁敏生[1] 欧香忠[1] 

机构地区：[1]中山医科大学附属第一医院内分泌科

出　　处：《中山医科大学学报》1998年第1期61-63,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：目的：观察母体血糖、胰岛素、空腹胎盘催乳素（ＨＰＬ）水平与胎儿体重之间的关系。方法：对６２例妊娠３２～３６周的正常孕妇进行７５ｇ糖耐量试验，同时检测空腹和餐后１ｈ、２ｈ血糖和胰岛素，以及ＨＰＬ的浓度，并跟踪其胎儿出生体重。结果：胎儿体重与母体餐后血糖及ＨＰＬ水平均显著正相关，Ｐ＜００１，Ｐ＜０００１；与空腹血糖及胰岛素水平无相关。多重回归分析显示，去除母体糖代谢因素影响后，ＨＰＬ仍与胎儿体重显著正相关，Ｐ＜００５。结论：生理范围的母体血糖水平变化与胎儿生长有密切关系。Objective:To observe the relationships of baby birthweight with maternal glucose, insulin and HPL levels. Methods:Human placental lactogen (HPL) levels, glucose and insulin concentrations of fasting and 1 hour, 2 hour after 75g glucose load were tested in 62 cases of normal pregnant women during 75g oral glucose tolerance tests (OGTT) at week 32～36 of pregnancy. The birthweights of the baby were recorded. Results:The birthweight was positively correlated with 1h, 2h glucose value (P<0.01) and HPL(P<0.001),but was not correlated with insulin concentrations and fasting glucose concentration. The correlation between birthweight and HPL level persisted (P<0.05) when maternal glucose concentrations, insulin concentrations and BMI were taken into account in a multiple regression. Conclusions: Physiologic changes of maternal carbohydrate metabolism are significantly related to fatal growth, and the influence of HPL on fatal growth is not totally through maternal carbohydrate metabolism changes.

关 键 词：胎盘催乳激素 胎儿生长 糖代谢 

分 类 号：R714.147[医药卫生—妇产科学] R714.51[医药卫生—临床医学]