白芍总甙对大鼠红细胞膜ATP酶活性的影响  

Effects of total glucosides of paeony on adenosinetriphosphatase activities of erythrocyte membranes of rats

作　　者：王斌[1,2] 杜冠华[1,2] 陈敏珠[1,2] 

机构地区：[1]安徽医科大学临床药理研究所 [2]中国医学科学院药物研究所

出　　处：《安徽医科大学学报》1998年第3期176-177,共2页Acta Universitatis Medicinalis Anhui

摘　　要：目的研究不同浓度白芍总甙（ＴＧＰ）对Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶和Ｎａ＋－Ｋ＋－ＡＴＰ酶活性的影响。方法制备大鼠红细胞膜和测定Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶和Ｎａ＋－Ｋ＋－ＡＴＰ酶活性。结果较高浓度ＴＧＰ（２０～４０ｍｇＬ－１）可明显提高两酶活性。Objective To study the effects of different concentrations of total glucosides of paenoy(TGP) on calciummagnesiumadenosine triphosphatase (Ca^2+Mg^2+ATPase) and sodiumpotassiumadenosine triphosphatase (Na^+K^+ATPase) activity. Methods Erythrocyte membranes from rats were prepared, Ca^2+Mg^2+ATPase and Na^+K^+ATPase activity was measured. Results Higher concentrations (20￣40 mg·L^-1) of TGP could significantly enhance both the Ca^2+Mg^2+ATPase and Na^+K^+ATPase activity. Connclusion Cytoplasmic free Ca^2+ concentration reduced by higher concentrations of TGP was associated with its enhancement of Ca~2+Mg^2+ATPase and Na^+K^+ATPase activity.

关 键 词：白芍 皂甙 ATP酶 红细胞膜 大鼠 白芍总甙 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]