扩张型心肌病患者外周血淋巴细胞β肾上腺素能受体的变化  

Change of β-adrenoceptor density of lymphocytes in patients with dilated cardiomyopathy

作　　者：丁荣华[1] 黄峻[1] 黄元铸[1] 马文珠[1] 王敬良[1] 

机构地区：[1]南京医科大学第一附属医院心内科,210029

出　　处：《临床心血管病杂志》1998年第3期137-139,共3页Journal of Clinical Cardiology

摘　　要：观察17例扩张型心肌病（DCM）患者的外周血淋巴细胞β肾上腺素能受体（β受体）、血浆去甲肾上腺素（NE）、异丙肾上腺素敏感试验ICD25及心功能。结果显示：DCM患者的外周血淋巴细胞β受体数目下降，且与心功能呈正相关，NE及ICD25增高。10例接受近5个月的美托洛尔治疗后，外周血淋巴细胞β受体上升，心功能改善；血浆NE及ICD25下降。表明：β受体的下调在DCM的发生、发展中起重要作用。This study evaluated β-adrenoceptor density of lymphocytes, plasma norepinephrine,isoprenaline sensitivity test (ICD25) and cardiac function in 17 patients with dilated cardiomyopathy. 10/17 patients were treated with metoprolol. Results showed that β-adrenoceptor density of lymphocytes was decrease and correlative with cardiac function,plasma norepinephrine and (ICD25)were increase compared with control. After treatment with metoprolol for five months,β-adrenoceptor density of lymphocytes was increase, cardiac function improved, plasma norepinephrine and ICD2,were decrease. Our data suggests:decrease of β-adrenoceptor density of lymphocytes may play an important role in dilated cardiomyopathy.

关 键 词：扩张型 心肌病 Β受体 肾上腺素 

分 类 号：R542.2[医药卫生—心血管疾病]