充血性心力衰竭患者线粒体DNA缺失的意义  

Significance of mitochondrial DNA deletion in congestive heart failure

作　　者：赵志明[1] 李庚山[2] 许家琍[2] 蒋锡嘉[2] 

机构地区：[1]湖北医科大学附属第一医院老年病科,武汉430060 [2]湖北医科大学附属第一医院心内科

出　　处：《临床心血管病杂志》1998年第3期148-150,共3页Journal of Clinical Cardiology

摘　　要：为探讨线粒体DNA（mtDNA）5．0kb缺失与充血性心力衰竭（CHF）发病的关系，应用聚合酶链反应（PCR）技术分析72例CHF患者的mtDNA。结果显示，CHF患者mtDNA5．0kb缺失率明显高于对照组（0.254％±0．08％比0．032％±0．01％，P＜0．01）；CHF组内扩张型心肌病组及冠心病组mtDNA5．0kb缺失率高于风心病及高血压心脏病组（P＜0．05）。研究中还发现，随着心功能分级增加，mtDNA5．0kb缺失率增高（P＜0．05）。提示mtDNA缺失影响心肌细胞线粒体呼吸功能，心肌能量供应障碍与CHF的发生、发展有关。The relationship between mitochondrial DNA (mtDNA)5. 0 kb deletion and congestive heart failure (CHF)was investigated in 72 CHF patients by polymerase chain reaction (PCR)technique. The results showed much higher levels of mtDNA 5. 0 kb deletion in the patients of CHF than in those of control(0. 254±0. 08% vs 0. 032±0. 01 %, P <0. 01). The levels of mtDNA 5. 0kb deletion in the group of coronary artery disease and dilated cardiomyopathy were much higher than in those of rheumatic heart disease and hypertensive heart disease,respectively(P <0. 05).The study also demonstrated the levels of mtDNA 5. 0 kb deletion were increased with the increased heart functional classes (P <0. 05). Thus,mtDNA deletion may effect the developmental mechanism of CHF.

关 键 词：充血性心力衰竭 线粒体 DNA缺失 

分 类 号：R541.61[医药卫生—心血管疾病]