肝脏胆红素葡萄糖醛酸基转移酶活性与胆色素结石形成的关系  

The relationship between the hepatic bilirubin UDP-glucuronyitransferase activity and the formation of pigment gallstones.

作　　者：杨文奇[1] 程锡魁[1] 祝学光[1] 张红军[1] 赵华[1] 

机构地区：[1]北京医科大学人民医院外科

出　　处：《中华实验外科杂志》1998年第4期337-338,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(No.39470680)

摘　　要：目的探讨肝脏胆红素尿苷二磷酸葡萄糖醛酸基转移酶(B-UGT)活性与胆色素结石形成的关系。方法检测胆色素结石病人及动物模型肝组织中B-UGT活性和胆汁中单结合胆红素(MCB)所占比例。结果胆色素结石病人及动物模型肝组织中B-UGT活性均显著低于相应对照组(P<0.05),而两胆石组胆囊胆汁中MCB所占比例均明显增多,胆色素结石病人组MCB所占比例为35%±5%,动物模型组MCB所占比例为72.3%±4.7%。结论肝脏B-UGT活性下降可能通过胆汁中MCB含量的增多而参与胆色素结石的形成。Objective To investigate the relationship between the hepatic bilirubin UDP-glucuronyltransferase (B-UGT) activity and the formation of pigment gallstones. Methods The hepatic B-UGT activity and the proportion of biliary monoconjugated bilirubin (MCB) in 6 patients with pigment gallstones and 16 golden Syrian hamsters with experimental gallstones were determined. Results The mean activities of hepatic B-UGT in the patients and animal models with pigment gallstones were lower than the matched normal controls (P<0.05) ; the proportion of biliary MCB in the patients and the hamsters with pigment gallstones were increased significantly with the percentage of biliary MCB in the patients and the litho-genesis hamsters being 35%±5% and 72.3%±4.7%, respectively. Conclusion A decreased hepatic B-UGT activity might contribute to the formation of pigment gallstones by rendering an increased propor-tion of biliary MCB.

关 键 词：胆结石 胆色素结石 B-UGT 动物模型 

分 类 号：R657.42[医药卫生—外科学]