鼻敏片对大鼠变应性鼻炎鼻黏膜ICAM-1、VCAM-1表达的影响  

Effect of Bimin Tablet on ICAM-1 and VCAM-1 expression in nasal mucosa of exprimental allergic rhinitis in rats

作　　者：刘密[1] 姚佳 李曼[1] 李凡成[1] 李韵霞[3] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湘西土家族苗族自治州民族中医院,湖南吉首416000 [3]深圳市中医院,广东深圳518033

出　　处：《湖南中医药大学学报》2009年第2期29-31,共3页Journal of Hunan University of Chinese Medicine

基　　金：湖南省科技厅资助项目(06SK3074);湖南省教育厅资助项目(06C619);湖南省教育厅重点学科"中医五官科学"资助项目

摘　　要：目的研究鼻敏片对大鼠变应性鼻炎鼻黏膜ICAM-1、VCAM-1表达的影响。方法将SD大鼠先用卵清白蛋白经腹腔内注射致敏,然后鼻腔滴入卵清白蛋白,造成变应性鼻炎模型,随机分为空白对照组、模型组、鼻敏片低剂量组、鼻敏片高剂量组、开瑞坦组各10只,均治疗15 d。结果与空白对照组比,变应性鼻炎各组ICAM-1、VCAM-1的阳性细胞表达数明显增加,差异具有统计学意义(P<0.01);与模型组相比,ICAM-1表达均被鼻敏片和开瑞坦所抑制,差异具有统计学意义(P<0.01);VCAM-1的表达均被鼻敏片高剂量组和开瑞坦组具有抑制作用,差异具有统计学意义(P<0.01)。结论鼻敏片能抑制变应性鼻炎大鼠鼻黏膜ICAM-1、VCAM-1的表达。Objective TO investigate the effect of Bimin Tablet （BMT） on ICAM-1 （Intercellular adhesion molecule-1） and VCAM-1 （Vascular cell adhesion molecule-1） expression in nasal mucosa of experimental allergic rhinitis in rats. Method SD rats models, immunized by intraperitoneal injection of Ovalbumin（OVA）, then instilled OVA into nasal cavity, were random-Ly divided into four group： allergic rhinitis model group （n=10）; the higher dose group of BMT （n=10）; the lower dose group of BMT （n=10）; Kairuitan treated group （n=10）. All animals were treated for 15 days. Result The number of positive immunoreactive cells（ICAM-1 and VCAM-1） was increased significantly in all the groups compared with normal group （P〈0.01）. ICAM-1 expression was inhibited by giving with Bimin Tablet and Kairuitan comparedwith allergic rhinitis model group（P〈0.01）; VCAM-1 expression was inhibited by giving with Bimin Tablet （especially in the higher dose group of BMT） and Kairuitan comparedwith allergic rhinitis model group （P〈 0.01）. Conclusion Bimin Tablet can decrease the expression of ICAM-1 and VCAM-1 in nasal mucosa of experimental allergic rhinitis.

关 键 词：鼻敏片 变态反应性鼻炎 细胞黏附分子 ICAM-1 VCAM-1 大鼠 

分 类 号：R285.5[医药卫生—中药学]