祛风止动方治疗儿童抽动障碍31例临床研究  

Clinical Study on the Effect of Qufeng Zhidong Decoction on 31 Cases of Children Tic Disorder

作　　者：吴敏[1] 肖光华[2] 张建明[1] 张欣[1] 马博[2] 王树霞[2] 周亚兵[1] 张婧延[3] 

机构地区：[1]上海交通大学医学院附属新华医院中医科,上海市200092 [2]上海交通大学医学院 [3]上海中医药大学附属龙华医院

出　　处：《中医杂志》2009年第5期408-412,共5页Journal of Traditional Chinese Medicine

基　　金：上海市卫生局基金资助项目(2006L014);申康医院发展中心基金资助项目(SHDC12007409);上海市中医临床优势专科(专病)第二批建设项目(2008YSZK003)

摘　　要：目的评价祛风止动方治疗儿童抽动障碍(TD)的临床疗效与不良反应。方法将入选患儿随机分为中药组(31例)和西药组(30例),中药组以祛风止动方治疗,西药组予氟哌啶醇和苯海索片。12周为1个疗程,观察2个疗程,以耶鲁综合抽动严重程度量表(YGTSS)、抽动症状评分量表(TSSS)、中医证候评分量表(TCMSSS)以及治疗副反应量表(TESS)、实验室检查评价临床疗效与不良反应。结果中药组和西药组总有效率分别为100%、60.0%,差异有统计学意义(P<0.05);在各项评分方面中药组均优于西药组(P<0.05)。结论祛风止动方能显著改善TD患儿抽动症状及体征,且无毒副作用。Objective To assess the effect and adverse effect of Qufeng Zhidong Decoction （Decoction for Dispelling wind to stop abnormal movements） on children Tic Disorder （TD）. Methods The enrolled patients were randomized into TCM group （31 cases） and western medicine group （30 cases）. The former was treated with Qufeng Zhidong Decoction while the latter treated with haloperidol and trihexyphenidyl. Twelve weeks was of one course of treatment. Two courses were observed. The therapeutic and adverse effects were assessed by Yale Global Tic Severity Scale （YGTSS）, Tic Symptom Score Scale （TSSS）, Traditional Chinese Medicine Syn- drome Score Scale （TCMSSS）, Treatment Emergent Symptom Scale （TESS） and laboratory examinations. Results The total effective rate of TCM group and western medicine groups were 100% and 60.0% respectively, the difference was significant （P〉0.05）. All the scores of TCM group were better than those of western medicine group （P〈0.05）. Conclusion Qufeng Zhidong Decoction could significantly improve symptoms and signs of TD children without adverse effect.

关 键 词：抽动障碍 祛风止动方 耶鲁综合抽动严重程度量表 抽动症状评分量表 中医证候评分量表 临床观察 

分 类 号：R272[医药卫生—中医儿科学]