2-巯基-5,7-二甲基-1,2,4-三唑并[1,5-α]嘧啶的合成  

Synthesis of 2-mercapto-5,7-dimethyl-1,2,4-triazolo[1,5-α] pyrimidine

作　　者：管有志[1] 陈天云[1] 吴海涛[1] 

机构地区：[1]合肥工业大学化工学院,安徽合肥230009

出　　处：《化工时刊》2009年第5期53-55,63,共4页Chemical Industry Times

摘　　要：2-巯基-5,7-二甲基-1,2,4-三唑并[1,5-α]嘧啶是合成三唑并嘧啶类衍生物的重要中间体。实验研究了以5-氨基-3-巯基-1,2,4-嘧啶为原料,与乙酰丙酮环合制备2-巯基-5,7-二甲基-1,2,4-三唑并[1,5-α]嘧啶的工艺条件,研究结果表明,在AMZ与乙酰丙酮物质的量比为1∶1.1、反应温度为120℃、反应时间为10 h时,2-巯基-5,7-二甲基-1,2,4-三唑并[1,5-α]嘧啶的收率达到80%。2 - mercapto - 5,7 - dimethyl - 1,2,4 - triazolo[ 1,5 - α] pyrimidine is an important intermediate of Synthesisl ,2,4triazolo[ 1,5 - α] pyrimidine derivatives. It was synthesized by eyclization of 5 - amino -3 - mercapto - 1,2,4 - triazole with the aeetyl acetone. The results of the experiment showed that when the molar of AMZ to acetyl acetone was 1：1.1,the reaction temperature was 120℃, the reaction time was 10h, the yield of 2 -mercapto -1,2, 4 - trito -5,7 - dimethyl - 1,2,4 - triazolo [ 1,5 - α ] pyrimidine was up to 80%.

关 键 词：3-氨基-5-巯基-1 2 4-嘧啶 2-巯基-5 7-二甲基-1 2 4-三唑并[1 5-α]嘧啶 环化反应 

分 类 号：TQ252[化学工程—有机化工]