止咳平喘缓释片体外释放度的研究  

Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets

作　　者：李晓燕[1] 冯中[1] 霍务贞[1] 李苑新[1] 王博[1] 朱盛山[1] 

机构地区：[1]广东药学院中药开发研究所,广州510006

出　　处：《中国中药杂志》2009年第10期1216-1219,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30672670);国家科技部"十一五"支撑项目(2006BAIOPB08-02);广州市重大科技计划专项项目(2008A1-E4101-3)

摘　　要：目的:建立止咳平喘缓释片体外均衡释放的评价方法。方法:以麻黄碱、伪麻黄碱、东莨菪碱为指标成分,以色谱基线分离和理论塔板数考察选择止咳平喘缓释片体外释放度评价测定色谱条件;以3个指标成分的释放度曲线条件评价缓释片是否均衡释放。结果:与止咳平喘普通片相比,止咳平喘缓释片3个指标成分在10 h内成均衡释放。结论:止咳平喘缓释片释放度测定选择的3个指标成分和2个色谱条件可作为建立该缓释片均衡释放度评价方法的基础。Objective：To establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets. Method： The ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not. Result： Compared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h. Conclusion： The maker components of Zhike Pingchuan sustained-release tablets and two chromatographic conditions, which were used to determine the dissolution of the sustained-release tablets, could be chosen as evaluation methods for the in vitro release of Zhike Pingchuan sustained-release tablets.

关 键 词：止咳平喘 缓释片 释放度 评价方法 

分 类 号：R283[医药卫生—中药学]