云木香化学成分研究  

Study on chemical constituents from roots of Saussurea lappa

作　　者：张婷[1] 王洪庆[1] 杜冠华[1] 陈若芸[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050

出　　处：《中国中药杂志》2009年第10期1223-1224,共2页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30630073)

摘　　要：目的:研究菊科风毛菊属植物云木香的化学成分。方法:利用硅胶柱色谱、Sephadex LH-20和反相RP-18柱色谱等手段进行分离纯化,并通过波谱数据鉴定结构。结果:分离鉴定了11个化合物,5,7-二羟基-2-甲基色原酮(5,7-dihydroxy-2-methylchromone,1),对羟基苯甲醛(p-hydroxybenzaldehyde,2),3,5-二甲氧基-4-羟基苯甲醛(3,5-dimethoxy-4-hydroxy-benzalde-hyde,3),3,5-二甲氧基-4-羟基苯乙酮(3,5-dimethoxy-4-hydroxyacetophenone,4),ethyl 2-pyrrolidinone-5(s)-carboxylate(5),5-羟甲基糠醛(5-hydroxymethyl-furaldehyde,6),棕榈酸(palmitic acid,7),丁二酸(succinic acid,8),葡萄糖(glucose,9),胡萝卜苷(daucosterol,10),β-谷甾醇(β-sitosterol,11)。结论:化合物1,2,4,5,7,9为首次从该属植物中分离得到,且化合物5为首次从天然产物中分离得到。Objective： To study the chemical constituents in roots of Saussurea lappa. Method： Isolation and purification were carried out by silica gel, Sephadex LH-20 and RP-18 column chromatography. The chemical structures of constituents were elucidated on the basis of spectral data. Result： Eleven compounds were isolated and identified as ： 5,7-dihydroxy-2-methylchromone （ 1 ）, phydroxybenzaldehyde （2）, 3,5-dimetboxy--4-hydroxy-benzaldehyde （3）, 3,5- dimethoxy-4-hydroxy-acetophenone （4）, ethyl 2-pyrrolidinone-5 （s） -carboxylate （ 5 ）, 5-hydroxymethyl- furaldehyde （6）, palmitic acid （ 7）, succinic acid （ 8）, glucose （ 9）, daucosterol （10）,β-sitosterol （11）. Conclusion： Compounds 1, 2, 4, 5, 7, 9 were isolated from the genus Saussurea for the first time.

关 键 词：菊科 风毛菊属 云木香 

分 类 号：R284[医药卫生—中药学]