全身炎症反应综合征患儿肝酶水平变化及其临床意义  

Liver Enzyme Levers in Children with Systemic Inflammatory Response Syndrome

作　　者：陈新[1] 陈彩玲[1] 罗分平[1] 封志纯[1] 

机构地区：[1]北京军区总医院附属八一儿童医院儿童内科,北京100710

出　　处：《中国误诊学杂志》2009年第17期4036-4037,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨全身炎症反应综合征(SIRS)患儿谷草转氨酶(AST)/谷丙转氨酶(ALT)比值变化及临床意义。方法:对收治的100例SIRS患儿,依是否发生多器官功能不全(MODS)分为MODS组和非MODS组,另以30例健康儿童作正常对照。检测AST/ALT比值,进行急性生理学及慢性健康状况评分(APACHE评分)。结果:MODS组AST/ALT比值、APACHE评分和病死率均显著高于非MODS组(P<0.05);随着病情的轻、中、重度变化,MODS组AST/ALT比值显著增高,APACHE评分和病死率亦显著增高,重度MODS组APACHE评分最高,预后最差(P<0.05);AST/ALT比值介于1.3±0.7和2.8±0.8之间时,患儿预后尚好;AST/ALT比值<1.3±0.7或>2.8±0.8时,预后欠佳。结论:AST/ALT在SIRS患儿的发病过程中发生明显变化并影响预后,其可作为判断SIRS预后的简易可靠指标之一。Objective：To research the effect of the value of AST/ALT onsystemic inflammatory response syndrome （SIRS）of children. Methods ：One hundrend children with SIRS were studied. They were divided into two groups on the basis of multiorgan dysfunction syndrome（MODS）or without MODS. Thirty healthy children were used as a control group. Acute physiology and chronic health evaluation （APACHE Ⅱ）was detected. Results：The value of AST/ALT,APACHE Ⅱ and death rate in MODS group was higher than that of non-MODS group（P〈0.05）. With the increasing of the value of AST/ALT in MODS groups,APACHE Ⅱ and death rate increased distinctively（P〈0.05）. APACHE Ⅱ and death rate in maximal value of AST/ALT group was the highest compared with that of other groups. When the val ue of AST/ALT was 1.3±0.7 to 2.8±0.8,the prognosis of children with SIRS was better. Otherwise,it was harmful. Conclusions ：AST/ALT participated in process of SIRS and influenced its prognosis. It should be regarded as one of the simple and dependable index to judge prognosis in children with SIDS.

关 键 词：脓毒症综合征/酶学 天冬氨酸氨基转移酶类/分析 丙氨酸转氨酶/分析 人类 

分 类 号：R631[医药卫生—外科学]